PRNPIP Antibody (F-3): sc-515164

PRNPIP Antibody (F-3) is a mouse monoclonal IgG1 antibody that detects PRNPIP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRNPIP, also known as prion protein-interacting protein, plays a crucial role in the regulation of prion protein metabolism and is involved in the cellular response to prion diseases. This 337 amino acid protein is predominantly expressed in the brain, thyroid, testis, and heart, highlighting its significance in various physiological processes. Notably, PRNPIP interacts with the cellular form of the prion protein (PrPc), influencing its stability and potentially modulating the conversion to the pathogenic form (PrPSc). The presence of three isoforms of PRNPIP, generated through alternative splicing, suggests a complex regulatory mechanism that may be essential for maintaining cellular homeostasis and responding to neurodegenerative challenges. The unique properties of PRNPIP, including its expression patterns and interactions, underscore its importance in understanding prion diseases and developing therapeutic strategies. Anti-PRNPIP antibody (F-3) is an invaluable tool for researchers investigating the molecular underpinnings of prion-related disorders and the broader implications of prion protein dynamics.

The preferred PRNPIP antibody is PRNPIP Antibody (F-10): sc-514310.