PRNPIP Antibody (F-10): sc-514310
- PRNPIP Antibody (F-10) is a mouse monoclonal IgG2a κ PRNPIP antibody provided at 200 µg/ml
- raised against amino acids 206-305 mapping within an internal region of PRNPIP of human origin
- PRNPIP Antibody (F-10) is recommended for detection of PRNPIP of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PRNPIP Antibody (F-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PRNPIP Antibody (F-10) for WB applications. These reagents are now offered in bundles with PRNPIP Antibody (F-10) (see ordering information below).
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SEE ALSO...
PRNPIP Antibody (F-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects PRNPIP of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRNPIP (F-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRNPIP, also known as prion protein-interacting protein, plays a crucial role in the pathogenesis of prion diseases, which are lethal neurodegenerative disorders characterized by the misfolding of the prion protein (PrP). Specifically, PRNPIP interacts with the cellular form of PrP, known as PrPc, which is predominantly located in the brain, thyroid, testis, and heart. This interaction is vital as PRNPIP may influence the conversion of PrPc to the disease-associated form, PrPSc, thereby impacting the progression of prion diseases. PRNPIP is composed of 337 amino acids and exists in three isoforms due to alternative splicing, highlighting its complexity and potential regulatory roles in cellular processes. Understanding the function and interactions of PRNPIP is essential for elucidating the mechanisms underlying prion diseases and developing therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PRNPIP Antibody (F-10) References:
- PrPC directly interacts with proteins involved in signaling pathways. | Spielhaupter, C. and Schätzl, HM. 2001. J Biol Chem. 276: 44604-12. PMID: 11571277
- New insights into cellular prion protein (PrPc) functions: the 'ying and yang' of a relevant protein. | Nicolas, O., et al. 2009. Brain Res Rev. 61: 170-84. PMID: 19523487
- Thoughts on mammalian prion strains. | Weissmann, C. 2009. Folia Neuropathol. 47: 104-13. PMID: 19618334
- Prion protein: From physiology to cancer biology. | Mehrpour, M. and Codogno, P. 2010. Cancer Lett. 290: 1-23. PMID: 19674833
- Prions: protein aggregation and infectious diseases. | Aguzzi, A. and Calella, AM. 2009. Physiol Rev. 89: 1105-52. PMID: 19789378
- Prion protein misfolding. | Kupfer, L., et al. 2009. Curr Mol Med. 9: 826-35. PMID: 19860662
- PrP interactions with nucleic acids and glycosaminoglycans in function and disease. | Silva, JL., et al. 2010. Front Biosci (Landmark Ed). 15: 132-50. PMID: 20036811
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRNPIP Antibody (F-10) | sc-514310 | 200 µg/ml | $322.00 | |||
PRNPIP Antibody (F-10): m-IgG Fc BP-HRP Bundle | sc-531088 | 200 µg Ab; 10 µg BP | $361.00 | |||
PRNPIP Antibody (F-10): m-IgGκ BP-HRP Bundle | sc-524683 | 200 µg Ab, 40 µg BP | $361.00 | |||
PRNPIP Antibody (F-10): m-IgG2a BP-HRP Bundle | sc-547682 | 200 µg Ab; 10 µg BP | $361.00 | |||
PRNPIP Antibody (F-10) AC | sc-514310 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PRNPIP Antibody (F-10) HRP | sc-514310 HRP | 200 µg/ml | $322.00 | |||
PRNPIP Antibody (F-10) FITC | sc-514310 FITC | 200 µg/ml | $336.00 | |||
PRNPIP Antibody (F-10) PE | sc-514310 PE | 200 µg/ml | $349.00 | |||
PRNPIP Antibody (F-10) Alexa Fluor® 488 | sc-514310 AF488 | 200 µg/ml | $364.00 | |||
PRNPIP Antibody (F-10) Alexa Fluor® 546 | sc-514310 AF546 | 200 µg/ml | $364.00 | |||
PRNPIP Antibody (F-10) Alexa Fluor® 594 | sc-514310 AF594 | 200 µg/ml | $364.00 | |||
PRNPIP Antibody (F-10) Alexa Fluor® 647 | sc-514310 AF647 | 200 µg/ml | $364.00 | |||
PRNPIP Antibody (F-10) Alexa Fluor® 680 | sc-514310 AF680 | 200 µg/ml | $364.00 | |||
PRNPIP Antibody (F-10) Alexa Fluor® 790 | sc-514310 AF790 | 200 µg/ml | $364.00 |