PP2A-Aα/β Antibody (3J18): sc-80989
- PP2A-Aα/β Antibody (3J18) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against a synthetic peptide corresponding to the N-teminal region of human PP2A-A
- recommended for detection of PP2A-Aα and PP2A-Aβ of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See PP2A-Aα (6G3): sc-56954 for PP2A-Aα/β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PP2A-Aα/β Antibody (3J18) for WB and IHC(P) applications. These reagents are now offered in bundles with PP2A-Aα/β Antibody (3J18) (see ordering information below).
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PP2A-Aα/β Antibody (3J18) is a mouse monoclonal IgG1 antibody that detects PP2A-Aα/β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). PP2A-Aα/β plays a crucial role in cellular signaling pathways by acting as a regulatory subunit of the protein phosphatase 2A (PP2A) complex, which is essential for the dephosphorylation of serine and threonine residues on target proteins. This dephosphorylation is vital for various cellular processes, including cell division, apoptosis, and maintaining cellular homeostasis. The PP2A complex is known for modulating the activity of numerous signaling pathways, including those involved in cancer progression and neurodegenerative diseases, making PP2A-Aα/β a significant focus of research in understanding these conditions. The interaction of PP2A-Aα/β with different regulatory subunits allows for a diverse range of substrate specificity and functional outcomes, highlighting PP2A-Aα/β′s importance in cellular regulation and signaling. Anti-PP2A-Aα/β antibody (3J18) enables researchers to gain insights into the dynamics of protein phosphorylation and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PP2A-Aα/β Antibody (3J18) References:
- The Interplay between PP2A and microRNAs in Leukemia. | Ruvolo, PP. 2015. Front Oncol. 5: 43. PMID: 25750899
- PP2A-B55 Holoenzyme Regulation and Cancer. | Goguet-Rubio, P., et al. 2020. Biomolecules. 10: PMID: 33266510
- PP2A activation targets AML stem cells. | Verrills, NM. 2022. Blood. 139: 1267-1269. PMID: 35238886
- Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation. | Peris, I., et al. 2023. Blood. 141: 1047-1059. PMID: 36455198
- Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2V617F myeloproliferative neoplasms. | Courdy, C., et al. 2023. Blood Cancer J. 13: 106. PMID: 37423955
- Regulation and role of the PP2A-B56 holoenzyme family in cancer. | Peris, I., et al. 2023. Biochim Biophys Acta Rev Cancer. 1878: 188953. PMID: 37437699
- NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis. | Han, WM., et al. 2024. Cell Death Discov. 10: 34. PMID: 38233385
- PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport. | Tziortzouda, P., et al. 2024. Acta Neuropathol. 147: 41. PMID: 38363426
- Retraction: Cancer-Associated PP2A Aα Subunits Induce Functional Haploinsufficiency and Tumorigenicity. | Chen, W., et al. 2024. Cancer Res. 84: 935. PMID: 38486488
- PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis. | Sanz-Flores, M., et al. 2024. Cell Rep. 43: 114494. PMID: 39003739
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2A-Aα/β Antibody (3J18) | sc-80989 | 100 µg/ml | $316.00 | |||
PP2A-Aα/β Antibody (3J18): m-IgG Fc BP-HRP Bundle | sc-537237 | 100 µg Ab; 10 µg BP | $354.00 | |||
PP2A-Aα/β Antibody (3J18): m-IgGκ BP-HRP Bundle | sc-534457 | 100 µg Ab; 40 µg BP | $354.00 |