PP2A-Aα/β Antibody (4G7): sc-13600
- PP2A-Aα/β Antibody (4G7) is a mouse monoclonal IgG1 κ PP2A-Aα/β antibody, cited in 18 publications, provided at 100 µg/ml
- raised against a synthetic peptide corresponding to the N-teminal region of human PP2A-A
- PP2A-A alpha / beta Antibody (4G7) is recommended for detection of PP2A-Aα and PP2A-Aβ of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-PP2A-A alpha / beta Antibody (4G7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PP2A-Aα/β Antibody (4G7) for WB and IHC(P) applications. These reagents are now offered in bundles with PP2A-Aα/β Antibody (4G7) (see ordering information below).
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PP2A-Aα/β Antibody (4G7) is a mouse monoclonal IgG1 kappa light chain antibody that detects PP2A-A alpha / beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PP2A-Aα/β (4G7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PP2A-A protein plays a crucial role in cellular signaling by acting as a serine/threonine phosphatase, which is essential for regulation of numerous cellular processes such as cell division, apoptosis, and maintaining cellular homeostasis. PP2A-A functions by dephosphorylating target proteins, thereby reversing kinase action and ensuring balanced phosphorylation within cells. This regulatory function controls various signaling pathways, including those involved in cancer progression and other diseases. PP2A family consists of several subunits, including PP2A-Aα and PP2A-Aβ, which can associate with different regulatory subunits to form a trimeric holoenzyme, highlighting complexity and versatility of regulatory mechanisms. Understanding PP2A-A interactions and functions is essential for elucidating roles in health and disease, making PP2A-Aα/β (4G7) antibody a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PP2A-Aα/β Antibody (4G7) References:
- Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B). | Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
- PP2A-Mediated Anticancer Therapy. | Chen, W., et al. 2013. Gastroenterol Res Pract. 2013: 675429. PMID: 24307892
- Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes. | Zhong, Y., et al. 2019. Nat Commun. 10: 4523. PMID: 31586053
- Selective PP2A Enhancement through Biased Heterotrimer Stabilization. | Leonard, D., et al. 2020. Cell. 181: 688-701.e16. PMID: 32315618
- The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. | Vervoort, SJ., et al. 2021. Cell. 184: 3143-3162.e32. PMID: 34004147
- Targeting PP2A for cancer therapeutic modulation. | Ronk, H., et al. 2022. Cancer Biol Med. 19: 1428-39. PMID: 36342229
- Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. | Van Eynde, A., et al. 1995. J Biol Chem. 270: 28068-74. PMID: 7499293
- Serine/threonine protein phosphatases. | Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
- Important roles for novel protein phosphatases dephosphorylating serine and threonine residues. | Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
- A regulatory subunit of smooth muscle myosin bound phosphatase. | Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
- Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. | Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
- Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. | Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2A-Aα/β Antibody (4G7) | sc-13600 | 100 µg/ml | $322.00 | |||
PP2A-Aα/β Antibody (4G7): m-IgG Fc BP-HRP Bundle | sc-526567 | 100 µg Ab; 10 µg BP | $361.00 | |||
PP2A-Aα/β Antibody (4G7): m-IgG1 BP-HRP Bundle | sc-531940 | 100 µg Ab; 20 µg BP | $361.00 | |||
PP2A-Aα/β Antibody (4G7) AC | sc-13600 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PP2A-Aα/β Antibody (4G7) HRP | sc-13600 HRP | 200 µg/ml | $322.00 | |||
PP2A-Aα/β Antibody (4G7) FITC | sc-13600 FITC | 200 µg/ml | $336.00 | |||
PP2A-Aα/β Antibody (4G7) PE | sc-13600 PE | 200 µg/ml | $349.00 | |||
PP2A-Aα/β Antibody (4G7) Alexa Fluor® 488 | sc-13600 AF488 | 200 µg/ml | $364.00 | |||
PP2A-Aα/β Antibody (4G7) Alexa Fluor® 546 | sc-13600 AF546 | 200 µg/ml | $364.00 | |||
PP2A-Aα/β Antibody (4G7) Alexa Fluor® 594 | sc-13600 AF594 | 200 µg/ml | $364.00 | |||
PP2A-Aα/β Antibody (4G7) Alexa Fluor® 647 | sc-13600 AF647 | 200 µg/ml | $364.00 | |||
PP2A-Aα/β Antibody (4G7) Alexa Fluor® 680 | sc-13600 AF680 | 200 µg/ml | $364.00 | |||
PP2A-Aα/β Antibody (4G7) Alexa Fluor® 790 | sc-13600 AF790 | 200 µg/ml | $364.00 |