POPX2 Antibody (G-11): sc-514793

POPX2 Antibody (G-11) is a mouse monoclonal IgG1 antibody that detects POPX2 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). POPX2, also known as partner of PIX 2, PPM1F, or CaM-kinase phosphatase, is a member of the PP2C family of serine/threonine phosphatases, which play a crucial role in regulating cellular stress response pathways. POPX2 is ubiquitously expressed, participating in various cellular processes, including the modulation of calcium/calmodulin-dependent protein kinase II (CaMKII) activity, which is vital for synaptic plasticity and memory formation. POPX2 interaction with PIX proteins and negative regulation of αPAK activity helps maintain cytoskeleton integrity by preventing actin stress fiber breakdown, thereby influencing cell shape and motility. Dysregulation of POPX2 expression can lead to pathological conditions, including caspase-dependent apoptosis, highlighting POPX2′s importance in cellular homeostasis and survival. With versatile applications and critical role in cellular signaling, anti-POPX2 antibody (G-11) serves as an essential tool for researchers studying phosphatase activity mechanisms and implications in health and disease.

The preferred POPX2 antibody is POPX2 Antibody (E-2): sc-514894.