Pol III RPC39 Antibody (RPC39): sc-21753
- Pol III RPC39 Antibody (RPC39) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against recombinant human RPC39, subunit of RNA polymerase III
- recommended for detection of the RPC 39 subunit of RNA polymerase III of mouse, rat and human origin by WB, IP, IF and IHC(P)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Pol III RPC39 Antibody (RPC39) for WB and IHC(P) applications. These reagents are now offered in bundles with Pol III RPC39 Antibody (RPC39) (see ordering information below).
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Pol III RPC39 Antibody (RPC39) is a mouse monoclonal IgG1 antibody that detects RPC39 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. RPC39 is a crucial component of RNA polymerase III, which is responsible for synthesizing essential small RNAs, including transfer RNA (tRNA) and 5S ribosomal RNA (rRNA). The proper functioning of RNA polymerase III is vital for protein synthesis and cellular function, as RPC39 ensures the availability of tRNAs necessary for translating mRNA into proteins. Disruptions in RNA polymerase III activity can lead to various diseases, including cancer, highlighting RPC39′s importance in maintaining cellular homeostasis. Anti-RPC39 antibody provides reliable detection and characterization of RPC39, facilitating research into gene expression and implications in health and disease.
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Pol III RPC39 Antibody (RPC39) References:
- A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. | Wong, RC., et al. 2011. Stem Cells. 29: 1517-27. PMID: 21898682
- Gene duplication and neofunctionalization: POLR3G and POLR3GL. | Renaud, M., et al. 2014. Genome Res. 24: 37-51. PMID: 24107381
- RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. | Lund, RJ., et al. 2017. Stem Cell Reports. 8: 1442-1454. PMID: 28494942
- Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development. | Wang, X., et al. 2020. Proc Natl Acad Sci U S A. 117: 15702-15711. PMID: 32576691
- Increased expression of POLR3G predicts poor prognosis in transitional cell carcinoma. | Liu, X., et al. 2020. PeerJ. 8: e10281. PMID: 33194434
- The POLR3G Subunit of Human RNA Polymerase III Regulates Tumorigenesis and Metastasis in Triple-Negative Breast Cancer. | Lautré, W., et al. 2022. Cancers (Basel). 14: PMID: 36497214
- Regulating POLR3G by MicroRNA-26a-5p as a promising therapeutic target of lung cancer stemness and chemosensitivity. | Park, CR., et al. 2023. Noncoding RNA Res. 8: 273-281. PMID: 36949748
- A Combinatorial Regulatory Platform Determines Expression of RNA Polymerase III Subunit RPC7α (POLR3G) in Cancer. | Cheng, R., et al. 2023. Cancers (Basel). 15: PMID: 37894362
- POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer. | Chen, H., et al. 2023. FASEB J. 37: e23260. PMID: 37933949
- The upregulation of POLR3G correlates with increased malignancy of bladder urothelium. | Liu, X., et al. 2024. Eur J Med Res. 29: 381. PMID: 39039528
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pol III RPC39 Antibody (RPC39) | sc-21753 | 200 µg/ml | $316.00 | |||
Pol III RPC39 Antibody (RPC39): m-IgG Fc BP-HRP Bundle | sc-536661 | 200 µg Ab; 10 µg BP | $354.00 | |||
Pol III RPC39 Antibody (RPC39): m-IgGκ BP-HRP Bundle | sc-533820 | 200 µg Ab; 40 µg BP | $354.00 | |||
Pol III RPC39 Antibody (RPC39): m-IgG1 BP-HRP Bundle | sc-544745 | 200 µg Ab; 20 µg BP | $354.00 |