PGC-1β Antibody (E-9): sc-373771

PGC-1β Antibody (E-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects PGC-1 beta protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PGC-1β antibody (E-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PGC-1 beta protein plays a crucial role in cellular energy metabolism, acting as a transcriptional coactivator that regulates genes involved in mitochondrial biogenesis and oxidative metabolism. PGC-1 beta protein′s ability to interact with key transcription factors such as nuclear respiratory factor-1 (NRF-1), estrogen receptor alpha (ERα), and glucocorticoid receptor (GR) underscores its importance in maintaining energy homeostasis and adapting to metabolic demands. PGC-1 beta protein is predominantly expressed in tissues with high energy requirements, such as the brain, heart, and skeletal muscle, and PGC-1 beta protein expression is modulated by various physiological signals, including insulin and fatty acids. Notably, the gene encoding PGC-1 beta is polymorphic, and variations in PGC-1 beta protein expression may influence susceptibility to metabolic disorders, including obesity. Using PGC-1β (E-9) antibody in your research can provide valuable insights into the regulatory mechanisms of energy metabolism and the potential implications for metabolic diseases.

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PGC-1β Antibody (E-9) References:

1. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha.  |  Kressler, D., et al. 2002. J Biol Chem. 277: 13918-25. PMID: 11854298
2. Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.  |  Huss, JM., et al. 2002. J Biol Chem. 277: 40265-74. PMID: 12181319
3. Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state.  |  Shiraki, T., et al. 2003. J Biol Chem. 278: 11344-50. PMID: 12551939
4. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.  |  Andersen, G., et al. 2005. J Med Genet. 42: 402-7. PMID: 15863669
5. Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro.  |  Staiger, H., et al. 2005. Diabetologia. 48: 2115-8. PMID: 16132959
6. Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.  |  Wirtenberger, M., et al. 2006. Carcinogenesis. 27: 2201-8. PMID: 16704985
7. Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids.  |  Hoeks, J., et al. 2006. Diabetologia. 49: 2419-26. PMID: 16896940
8. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.  |  Handschin, C. and Spiegelman, BM. 2006. Endocr Rev. 27: 728-35. PMID: 17018837
9. PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations.  |  Srivastava, S., et al. 2007. Hum Mol Genet. 16: 993-1005. PMID: 17341490
10. PGC-1beta: a co-activator that sets the tone for both basal and stress-stimulated mitochondrial activity.  |  Lelliott, CJ. and Vidal-Puig, A. 2009. Adv Exp Med Biol. 646: 133-9. PMID: 19536672
11. PGC-1β modulates statin-associated myotoxicity in mice.  |  Singh, F., et al. 2019. Arch Toxicol. 93: 487-504. PMID: 30511338
12. FOXO1 suppresses PGC-1β gene expression in skeletal muscles.  |  Nakai, S., et al. 2020. FEBS Open Bio. 10: 1373-1388. PMID: 32433820

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGC-1β Antibody (E-9) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-PGC-1β Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGC-1β Antibody (E-9) Specifications

Alternate Product Name: PPARGC1B

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 452-593

Epitope Target: PGC-1β

Epitope Species: mouse

Product Reactivity/Detection: PGC-1β

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for PGC-1β Antibody (E-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred PGC-1β antibody is PGC-1β Antibody (6C3F6): sc-517279.