PGC-1β Antibody (6C3F6): sc-517279
- PGC-1β Antibody (6C3F6) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against amino acids 195-414 of PGC-1β of Human origin
- PGC-1 beta Antibody (6C3F6) is recommended for detection of PGC-1β of human origin by WB, IP, FCM and ELISA
- Anti-PGC-1 beta Antibody (6C3F6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PGC-1β Antibody (6C3F6) for WB applications. This reagent is now offered in a bundle with PGC-1β Antibody (6C3F6) (see ordering information below).
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PGC-1β Antibody (6C3F6) is a mouse monoclonal IgG1 antibody that detects PGC-1β of human origin by western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). PGC-1β (6C3F6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PGC-1β, also known as PERC or PPARGC1B, plays a crucial role as a transcriptional coactivator that regulates mitochondrial biogenesis and energy metabolism. PGC-1β interacts with key transcription factors such as nuclear respiratory factor-1 (NRF-1), estrogen receptor alpha (ERα), and glucocorticoid receptor (GR), thereby influencing processes like energy expenditure and glucose metabolism. PGC-1β is predominantly expressed in tissues with high metabolic activity, including the brain, heart, and skeletal muscle, and expression is modulated by insulin and fatty acids. Notably, PGC-1β undergoes post-translational modifications, including phosphorylation and acetylation, which can significantly impact activity and stability, thereby affecting metabolic pathways and potentially contributing to metabolic disorders such as obesity. The gene encoding PGC-1β is polymorphic, and variations in expression may further influence individual susceptibility to metabolic diseases, making PGC-1β a critical target for research in metabolic regulation and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PGC-1β Antibody (6C3F6) References:
- PGC-1β regulates angiogenesis in skeletal muscle. | Rowe, GC., et al. 2011. Am J Physiol Endocrinol Metab. 301: E155-63. PMID: 21364124
- Age-dependent electrocardiographic changes in Pgc-1β deficient murine hearts. | Ahmad, S., et al. 2018. Clin Exp Pharmacol Physiol. 45: 174-186. PMID: 28949414
- PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes. | Brown, EL., et al. 2018. Front Physiol. 9: 1336. PMID: 30356878
- Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression. | Uchitomi, R., et al. 2019. Biochem Biophys Rep. 17: 51-55. PMID: 30582007
- MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα. | Yin, Z., et al. 2019. Cardiovasc Diabetol. 18: 7. PMID: 30635067
- PGC-1β Induces Susceptibility To Acetaminophen-Driven Acute Liver Failure. | Piccinin, E., et al. 2019. Sci Rep. 9: 16821. PMID: 31727907
- Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat. | Funda, J., et al. 2022. Dis Model Mech. 15: PMID: 35466996
- PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression. | Guak, H., et al. 2022. Sci Rep. 12: 16028. PMID: 36163487
- PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2. | Frodyma, DE., et al. 2022. Cancers (Basel). 14: PMID: 36230802
- Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts. | Torres, HM., et al. 2023. Mol Cell. 83: 3397-3399. PMID: 37802020
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGC-1β Antibody (6C3F6) | sc-517279 | 200 µg/ml | $316.00 | |||
PGC-1β Antibody (6C3F6): m-IgG Fc BP-HRP Bundle | sc-526442 | 200 µg Ab; 10 µg BP | $354.00 | |||
PGC-1β Antibody (6C3F6) AC | sc-517279 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PGC-1β Antibody (6C3F6) HRP | sc-517279 HRP | 200 µg/ml | $316.00 | |||
PGC-1β Antibody (6C3F6) FITC | sc-517279 FITC | 200 µg/ml | $330.00 | |||
PGC-1β Antibody (6C3F6) PE | sc-517279 PE | 200 µg/ml | $343.00 | |||
PGC-1β Antibody (6C3F6) Alexa Fluor® 488 | sc-517279 AF488 | 200 µg/ml | $357.00 | |||
PGC-1β Antibody (6C3F6) Alexa Fluor® 546 | sc-517279 AF546 | 200 µg/ml | $357.00 | |||
PGC-1β Antibody (6C3F6) Alexa Fluor® 594 | sc-517279 AF594 | 200 µg/ml | $357.00 | |||
PGC-1β Antibody (6C3F6) Alexa Fluor® 647 | sc-517279 AF647 | 200 µg/ml | $357.00 | |||
PGC-1β Antibody (6C3F6) Alexa Fluor® 680 | sc-517279 AF680 | 200 µg/ml | $357.00 | |||
PGC-1β Antibody (6C3F6) Alexa Fluor® 790 | sc-517279 AF790 | 200 µg/ml | $357.00 |