PGC-1β Activators
PGC-1β Activators refers to a class of chemical compounds that possess the unique ability to interact with and modulate the activity of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Beta (PGC-1β). PGC-1β is a transcriptional coactivator that plays a central role in regulating various aspects of cellular energy metabolism, mitochondrial biogenesis, and oxidative metabolism. It exerts its effects by interacting with and coactivating nuclear receptors and transcription factors that control genes involved in these processes. PGC-1β activators are compounds that can influence the expression or activity of PGC-1β, impacting cellular energy metabolism and mitochondrial function.
The mechanism of action of PGC-1β activators typically involves their ability to modulate the expression or post-translational modifications of PGC-1β. These activators may interact with PGC-1β directly, altering its stability, conformation, or activity. Alternatively, they may affect the signaling pathways and transcription factors that regulate PGC-1β expression, indirectly influencing its function. PGC-1β activators are of particular interest in the field of cellular metabolism and mitochondrial biology because they provide a means to fine-tune the metabolic responses of cells and tissues. By regulating PGC-1β activity, these compounds can influence energy production, mitochondrial biogenesis, and oxidative capacity, contributing to our understanding of the mechanisms that govern cellular metabolism and its adaptability to different physiological and environmental conditions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin, a widely used antidiabetic drug, may induce PGC-1β expression. It acts primarily by activating AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, which in turn can modulate PGC-1β activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid present in many fruits and vegetables, has been shown to activate AMPK, which may lead to an increase in PGC-1β expression and influence metabolic processes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, an alkaloid found in several plants, is known for its potential effects on glucose and lipid metabolism. It may induce PGC-1β expression through pathways involving AMPK and other metabolic regulators. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, a stimulant found in coffee and other beverages, may enhance mitochondrial biogenesis and function, possibly through the induction of PGC-1β. Its metabolic effects are linked to the modulation of various signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, is involved in cell differentiation and growth. It may upregulate PGC-1β expression, influencing energy metabolism and mitochondrial function. | ||||||
3,4-Dihydroxyphenyl Ethanol | 10597-60-1 | sc-202887 | 10 mg | $110.00 | 6 | |
3,4-Dihydroxyphenyl Ethanol, a phenolic compound found in olive oil, is known for its antioxidant properties. It may influence mitochondrial biogenesis and function by modulating PGC-1β expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane, a compound found in cruciferous vegetables, has been shown to affect various signaling pathways related to detoxification and antioxidant defenses. It may also influence PGC-1β expression. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Lipoic acid, an organosulfur compound found in octanoic acid, is involved in mitochondrial bioenergetics. It may enhance PGC-1β expression, contributing to its metabolic effects. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the main catechin in green tea, has been linked to various health benefits. It may induce PGC-1β expression, possibly through pathways involving AMPK and other metabolic regulators. | ||||||