PEPCK/PCK1/PCK2 Antibody (E-1): sc-271204

PEPCK Antibody (E-1) is a mouse monoclonal IgG2b kappa light chain antibody engineered to target Phosphoenolpyruvate carboxykinase (PEPCK), also known as PCK1 and PCK2. Anti-PEPCK antibody (E-1) is raised against amino acids 341-640 at the C-terminus of human PEPCK, ensuring precise recognition of both the mitochondrial form (PEPCK-M) and the cytosolic form (PEPCK-C) in mouse, rat, and human species. PEPCK is a key enzyme in the gluconeogenesis pathway, playing a critical role in the synthesis of glucose from non-carbohydrate sources. Structurally, PEPCK consists of distinct domains that facilitate catalytic activity and dimerization, which are essential for function in regulating glucose production in liver cells. The detailed structure of PEPCK allows effective interaction with substrates and regulatory molecules, making structural integrity vital for metabolic homeostasis. Dysregulation of PEPCK is closely linked to metabolic disorders such as type 2 diabetes and obesity, highlighting importance as a therapeutic target. PEPCK monoclonal antibody (E-1) is versatile in applications, suitable for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Additionally, PEPCK (E-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, providing flexibility for diverse experimental needs. By enabling precise detection and study of PEPCK′s structural and functional aspects, anti-PEPCK antibody (E-1) supports advanced research into metabolic regulation and development of potential treatments for insulin resistance and related conditions.

The preferred PEPCK/PCK1/PCK2 antibody is PEPCK/PCK1/PCK2 Antibody (F-3): sc-271029.