PDSS2 Antibody (F-5): sc-515136

PDSS2 Antibody (F-5) is a mouse monoclonal IgG2b antibody that detects Prenyl Diphosphate Synthase subunit 2 (PDSS2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDSS2 is a crucial enzyme that plays a significant role in the biosynthesis of coenzyme Q10, a vital component of the electron transport chain in mitochondria, which is essential for ATP production and cellular energy metabolism. The proper functioning of PDSS2 is critical, as defects in this protein can lead to coenzyme Q10 deficiency, resulting in severe clinical manifestations such as myopathy, encephalomyopathy, and ataxia, highlighting its importance in maintaining cellular energy homeostasis. PDSS2 exists as a heterotetramer composed of two PDSS2 and two PDSS1 subunits, and PDSS2 gene is located on chromosome 6q21, with two isoforms produced through alternative splicing. PDSS2 (F-5) antibody is an invaluable tool for researchers studying mitochondrial function and related disorders, providing insights into the molecular mechanisms underlying coenzyme Q10 deficiency and its associated phenotypes.

The preferred PDSS2 antibody is PDSS2 Antibody (C-12): sc-515137.