PDGF-D Antibody (E-6): sc-137031

PDGF-D Antibody (E-6) is a mouse monoclonal IgG2a antibody that detects PDGF-D in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDGF-D is a member of the platelet-derived growth factor family, which plays a crucial role in cell growth, survival, and tissue repair, particularly in connective tissue cells. PDGF-D is secreted as a disulphide-linked homodimer known as PDGF-DD, which is activated through limited proteolysis, allowing specific binding to and activation of the PDGFR-β receptor. The interaction between PDGF-D and PDGFR-β is vital for various biological processes, including the development of organ systems and wound healing. PDGF-D is predominantly expressed in fibroblastic adventitial cells, highlighting PDGF-D′s importance in the regulation of cellular functions within the extracellular matrix. Anti-PDGF-D antibody (E-6) provides a reliable tool for researchers studying the intricate signaling pathways mediated by PDGF-D and implications in health and disease.

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PDGF-D Antibody (E-6) References:

1. PDGF-D is a potent transforming and angiogenic growth factor.  |  Li, H., et al. 2003. Oncogene. 22: 1501-10. PMID: 12629513
2. Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family.  |  Reigstad, LJ., et al. 2005. FEBS J. 272: 5723-41. PMID: 16279938
3. Identification of platelet-derived growth factor D in human chronic allograft nephropathy.  |  Liu, G., et al. 2008. Hum Pathol. 39: 393-402. PMID: 18187181
4. Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells.  |  Kong, D., et al. 2008. Stem Cells. 26: 1425-35. PMID: 18403754
5. Platelet-Derived Growth Factor D Is a Prognostic Biomarker and Is Associated With Platinum Resistance in Epithelial Ovarian Cancer.  |  Zhang, M., et al. 2018. Int J Gynecol Cancer. 28: 323-331. PMID: 29240605
6. Platelet-derived growth factor-D promotes colorectal cancer cell migration, invasion and proliferation by regulating Notch1 and matrix metalloproteinase-9.  |  Jiang, B., et al. 2018. Oncol Lett. 15: 1573-1579. PMID: 29434852
7. Itraconazole Induces Regression of Infantile Hemangioma via Downregulation of the Platelet-Derived Growth Factor-D/PI3K/Akt/mTOR Pathway.  |  Chen, S., et al. 2019. J Invest Dermatol. 139: 1574-1582. PMID: 30690033
8. Dynamic Expression of Platelet-Derived Growth Factor-D and Phosphorylated Platelet-Derived Growth Factor Receptor-Β after Traumatic Brain Injury in Rats.  |  Cai, Z., et al. 2020. Clin Lab. 66: PMID: 33180440
9. PDGF-D Is Dispensable for the Development and Progression of Murine Alport Syndrome.  |  Firat, EAM., et al. 2024. Am J Pathol. 194: 641-655. PMID: 38309427
10. Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions.  |  Bernard, M., et al. 2024. Cell Mol Life Sci. 81: 225. PMID: 38769116

The preferred PDGF-D antibody is PDGF-D Antibody (E-7): sc-137029.