PDE1C Antibody (D-10): sc-166044

PDE1C Antibody (D-10) is a mouse monoclonal IgG2b antibody that detects phosphodiesterase 1C (PDE1C) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDE1C plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which are vital second messengers involved in various cellular processes, including signal transduction and cellular responses to hormones. PDE1C is predominantly located in the brain and heart, where PDE1C modulates important physiological functions such as cardiac contractility and neuronal signaling. Notably, PDE1C exists in two isoforms, PDE1C1 and PDE1C2, which arise from alternative splicing and exhibit distinct expression patterns; while both isoforms are present at low levels throughout the body, PDE1C2 is primarily found in the brain and heart, whereas PDE1C1 is also expressed in the lung. The ability of PDE1C to hydrolyze cAMP and cGMP is essential for maintaining cellular homeostasis and preventing excessive signaling, making PDE1C a significant target for therapeutic interventions in cardiovascular and neurological disorders. Anti-PDE1C antibody (D-10) is an invaluable tool for researchers studying the intricate roles of phosphodiesterases in health and disease.

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PDE1C Antibody (D-10) References:

1. The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion.  |  Han, P., et al. 1999. J Biol Chem. 274: 22337-44. PMID: 10428803
2. Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro.  |  Rowther, FB., et al. 2016. Mol Carcinog. 55: 268-79. PMID: 25620587
3. PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.  |  Knight, WE., et al. 2016. Proc Natl Acad Sci U S A. 113: E7116-E7125. PMID: 27791092
4. A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss.  |  Wang, L., et al. 2018. Hum Genet. 137: 437-446. PMID: 29860631
5. An EPAC1/PDE1C-Signaling Axis Regulates Formation of Leading-Edge Protrusion in Polarized Human Arterial Vascular Smooth Muscle Cells.  |  Brzezinska, P. and Maurice, DH. 2019. Cells. 8: PMID: 31757003
6. Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p.  |  Zhang, L., et al. 2021. Cell Cycle. 20: 1052-1066. PMID: 33945396
7. Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.  |  Zhang, C., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34312235
8. Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics.  |  Rexach, JE., et al. 2024. Cell. 187: 5753-5774.e28. PMID: 39265576
9. Circ-PDE1C/miR-766-3p/SGTB axis regulates the IL-1β-induced apoptosis, inflammation and oxidative stress in human chondrocytes.  |  Gao, L., et al. 2024. Adv Rheumatol. 64: 92. PMID: 39736775
10. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype.  |  Rybalkin, SD., et al. 1997. J Clin Invest. 100: 2611-21. PMID: 9366577

The preferred PDE1C antibody is PDE1C Antibody (G-7): sc-376474.