Pbx 2 Antibody (1.1): sc-101853

Pbx 2 Antibody (1.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pbx 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Pbx 2 antibody (1.1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Pbx 2 is a member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, which play crucial roles in developmental processes and gene regulation. Pbx 2 (1.1) monoclonal antibody forms protein complexes that regulate transcription, and interaction with other proteins, such as the E2A gene products, is significant in human pre-B cell acute leukemias, where chromosomal rearrangements can lead to oncogenic fusion proteins. Pbx genes, including Pbx 2, are ubiquitously expressed in both fetal and adult tissues, highlighting their importance in maintaining cellular functions across various biological contexts. Pbx 2 and Pbx 3 transcripts are specifically detected in lymphoid cells, indicating their potential roles in immune system development and function.

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Pbx 2 Antibody (1.1) References:

1. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.  |  Shen, WF., et al. 1999. Mol Cell Biol. 19: 3051-61. PMID: 10082572
2. Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.  |  Toresson, H., et al. 2000. Mech Dev. 94: 183-7. PMID: 10842069
3. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.  |  Wagner, K., et al. 2001. Mech Dev. 103: 127-31. PMID: 11335119
4. HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric complexes on HOXA10 target genes.  |  Sarno, JL., et al. 2005. J Clin Endocrinol Metab. 90: 522-8. PMID: 15494461
5. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.  |  Monica, K., et al. 1991. Mol Cell Biol. 11: 6149-57. PMID: 1682799
6. Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.  |  Qiu, Y., et al. 2009. Cancer Sci. 100: 1198-209. PMID: 19356220
7. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.  |  Nourse, J., et al. 1990. Cell. 60: 535-45. PMID: 1967982
8. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.  |  Kamps, MP., et al. 1990. Cell. 60: 547-55. PMID: 1967983
9. MicroRNA‑1915‑3p prevents the apoptosis of lung cancer cells by downregulating DRG2 and PBX2.  |  Xu, C., et al. 2016. Mol Med Rep. 13: 505-12. PMID: 26572100
10. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.  |  Lu, Q., et al. 1994. Mol Cell Biol. 14: 3938-48. PMID: 7910944
11. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.  |  Monica, K., et al. 1994. Mol Cell Biol. 14: 8304-14. PMID: 7969166
12. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.  |  LeBrun, DP. and Cleary, ML. 1994. Oncogene. 9: 1641-7. PMID: 8183558

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pbx 2 Antibody (1.1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Pbx 2 Antibody (1.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pbx 2 Antibody (1.1) Specifications

Alternate Product Name: Pbx 2

Product Clone Name: 1.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 307-430

Epitope Target: Pbx 2

Epitope Species: mouse

Product Reactivity/Detection: Pbx 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Pbx 2 Antibody (1.1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Pbx 1/2/3/4 antibody is Pbx 1/2/3/4 Antibody (F-3): sc-28313.