PBK Antibody (A-3): sc-393313

PBK Antibody (A-3) is a mouse monoclonal IgG2b antibody that detects PBK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PBK, or human PDZ-binding kinase, is a 322 amino acid serine/threonine kinase characterized by its T/SXV motif, which plays a crucial role in regulating various cellular processes, particularly in cell cycle control and proliferation. This protein is predominantly expressed in the placenta and is notably absent in adult brain tissue, highlighting its specific functional relevance in reproductive biology. The T/SXV motif of PBK allows interaction with PDZ domain-containing proteins, such as the tumor suppressor protein Dlg, facilitating critical signaling pathways that influence oncogenic potential through the phosphorylation of oncoproteins and tumor suppressor proteins. Additionally, PBK is activated by the cell cycle checkpoint kinase Cdc2/cyclin B, which underscores its importance in cell cycle regulation. Anti-PBK antibody (A-3) enables researchers to gain insights into PBK′s role in cellular proliferation and potential implications in cancer biology.

The preferred PBK antibody is PBK Antibody (B-10): sc-390399.