Pax-2 Antibody (60-P): sc-130387
- Pax-2 Antibody (60-P) is a mouse monoclonal IgG2a κ Pax-2 antibody, cited in 6 publications, provided at 100 µg/ml
- raised against recombinant PAX2 of human origin
- recommended for detection of Pax-2 of mouse, rat and human origin by WB and IP
- See Pax (D-7): sc-514352 for Pax-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Pax-2 (60-P): sc-130387.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Pax-2 Antibody (60-P) for WB applications. These reagents are now offered in bundles with Pax-2 Antibody (60-P) (see ordering information below).
Pax-2 Antibody (60-P) is a mouse monoclonal IgG2a kappa light chain antibody that detects Pax-2 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Pax-2 antibody (60-P) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical protein. Pax-2 protein plays a vital role in the development of various organs, including kidneys, eyes, and ears, by regulating gene expression involved in organogenesis. Proper Pax-2 function is essential for normal embryonic development, as mutations in PAX2 gene can lead to significant congenital anomalies, such as renal hypoplasia and various eye disorders, including retinal coloboma and microphthalmia. PAX2 expression in specific embryonic structures, such as optic vesicle and otic vesicle, highlights its importance in visual and auditory system formation. Understanding Pax-2′s role in these developmental processes not only sheds light on normal organ formation but also provides insights into developmental disorder mechanisms, making Pax-2 (60-P) antibody an invaluable resource for researchers investigating developmental biology and related pathologies.
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Pax-2 Antibody (60-P) References:
- Expression of the PAX2 gene in human embryos and exclusion in the CHARGE syndrome. | Tellier, AL., et al. 2000. Am J Med Genet. 93: 85-8. PMID: 10869107
- Paired box genes, PAX-2 and PAX-8, are not frequently mutated in Wilms tumor. | Tamimi, Y., et al. 2006. Mutat Res. 601: 46-50. PMID: 16814811
- bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure. | Villanueva, S., et al. 2006. Am J Physiol Regul Integr Comp Physiol. 291: R1677-87. PMID: 16873559
- Pax2/5/8 proteins promote cell survival in C. elegans. | Park, D., et al. 2006. Development. 133: 4193-202. PMID: 17021039
- Autosomal dominant aniridia: probable linkage to acid phosphatase-1 locus on chromosome 2. | Ferrell, RE., et al. 1980. Proc Natl Acad Sci U S A. 77: 1580-2. PMID: 6929510
- Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly. | Hanson, IM., et al. 1994. Nat Genet. 6: 168-73. PMID: 8162071
- PAX6 mutations in aniridia. | Hanson, IM., et al. 1993. Hum Mol Genet. 2: 915-20. PMID: 8364574
- Localisation of a 10q breakpoint within the PAX2 gene in a patient with a de novo t(10;13) translocation and optic nerve coloboma-renal disease. | Narahara, K., et al. 1997. J Med Genet. 34: 213-6. PMID: 9132492
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pax-2 Antibody (60-P) | sc-130387 | 100 µg/ml | $333.00 | |||
Pax-2 Antibody (60-P): m-IgG Fc BP-HRP Bundle | sc-537329 | 100 µg Ab; 10 µg BP | $354.00 | |||
Pax-2 Antibody (60-P): m-IgGκ BP-HRP Bundle | sc-534570 | 100 µg Ab; 40 µg BP | $354.00 |