Pax Antibody (D-7): sc-514352

Pax Antibody (D-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Pax protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Pax (D-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Pax protein plays a crucial role in regulating gene expression during embryonic development, influencing the differentiation of various cell types in a spatial and temporal manner. This regulation is vital for proper organ formation and tissue patterning, and disruptions in Pax protein function can lead to developmental disorders and contribute to the pathogenesis of various cancers. The Pax gene family, which consists of nine members, is characterized by paired domains that exhibit significant homology to Drosophila genes involved in early developmental programming. Understanding the function and interactions of Pax proteins is essential for elucidating their roles in both normal development and disease states, making anti-Pax antibody (D-7) a valuable tool for researchers studying these critical biological processes.

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Pax Antibody (D-7) References:

1. Expression of the PAX2 gene in human embryos and exclusion in the CHARGE syndrome.  |  Tellier, AL., et al. 2000. Am J Med Genet. 93: 85-8. PMID: 10869107
2. Pax7 is required for the specification of myogenic satellite cells.  |  Seale, P., et al. 2000. Cell. 102: 777-86. PMID: 11030621
3. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.  |  Adams, B., et al. 1992. Genes Dev. 6: 1589-607. PMID: 1516825
4. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.  |  Goulding, MD., et al. 1991. EMBO J. 10: 1135-47. PMID: 2022185
5. Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development.  |  Deutsch, U., et al. 1988. Cell. 53: 617-25. PMID: 2453291
6. Pax factors in transcription and epigenetic remodelling.  |  Mayran, A., et al. 2015. Semin Cell Dev Biol. 44: 135-44. PMID: 26234816
7. PAX transcription factors in neural crest development.  |  Monsoro-Burq, AH. 2015. Semin Cell Dev Biol. 44: 87-96. PMID: 26410165
8. PAX proteins and their role in pancreas.  |  Panneerselvam, A., et al. 2019. Diabetes Res Clin Pract. 155: 107792. PMID: 31325538
9. The Role of the PAX Genes in Renal Cell Carcinoma.  |  Li, L., et al. 2024. Int J Mol Sci. 25: PMID: 38928435
10. Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors.  |  Poleev, A., et al. 1995. Eur J Biochem. 228: 899-911. PMID: 7737192
11. Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.  |  Stapleton, P., et al. 1993. Nat Genet. 3: 292-8. PMID: 7981748
12. Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly.  |  Hanson, IM., et al. 1994. Nat Genet. 6: 168-73. PMID: 8162071

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pax Antibody (D-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Pax Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pax Antibody (D-7) Specifications

Alternate Product Name: Pax

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 72-150

Epitope Target: Pax-2

Epitope Species: human

Product Reactivity/Detection: Pax-1, Pax-2, Pax-3, Pax-5, Pax-6, Pax-7, Pax-8 and Pax-9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Pax Antibody (D-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred Pax-7 antibody is Pax-7 Antibody (PAX7): sc-81648.