Pax-7 Antibody (PAX7): sc-81648

Pax-7 Antibody (PAX7) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Pax-7, a crucial member of the paired box (PAX) family of nuclear transcription factors. Anti-Pax-7 antibody (PAX7) is raised against amino acids 352-523 of the chicken Pax-7 protein and demonstrates robust reactivity with Pax-7 from mouse, rat, human, and avian origins, making anti-Pax-7 antibody (PAX7) ideal for applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Pax-7 plays an essential role in embryonic development by regulating the temporal and spatial differentiation of muscle precursor cells, and Pax-7 is vital for the maintenance and function of satellite cells in adult muscle tissue. Pax-7 is involved in various signal transduction pathways that are critical for muscle regeneration and repair, highlighting Pax-7′s importance in both developmental biology and regenerative medicine. Additionally, mutations in the Pax-7 gene have been linked to diseases such as rhabdomyosarcoma, specifically the alveolar subtype (RMS2), underscoring Pax-7′s significance in cancer research. Available in both conjugated and non-conjugated forms, Pax-7 monoclonal antibody (PAX7) provides versatile tools for researchers to investigate the expression, function, and pathological roles of Pax-7 in muscle biology and related disorders. By targeting this key transcription factor, scientists can gain deeper insights into muscle development, regeneration, and the molecular mechanisms underlying muscle-related diseases.

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Pax-7 Antibody (PAX7) References:

1. Pax-7 immunoreactivity in the post-natal chicken central nervous system.  |  Shin, DH., et al. 2003. Anat Histol Embryol. 32: 378-83. PMID: 14651488
2. Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal.  |  Olguin, HC. and Olwin, BB. 2004. Dev Biol. 275: 375-88. PMID: 15501225
3. Myostatin imposes reversible quiescence on embryonic muscle precursors.  |  Amthor, H., et al. 2006. Dev Dyn. 235: 672-80. PMID: 16425219
4. Pax: a murine multigene family of paired box-containing genes.  |  Walther, C., et al. 1991. Genomics. 11: 424-34. PMID: 1685142
5. [Expression of fusion gene PAX3/PAX7-FKHR and chromosomal aberration in rhabdomyosarcoma].  |  Gao, H., et al. 2007. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 24: 42-7. PMID: 17285543
6. Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells.  |  Hicks, MR., et al. 2023. Nat Cell Biol. 25: 1758-1773. PMID: 37919520
7. Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors.  |  Mavrommatis, L., et al. 2023. Elife. 12: PMID: 37963071
8. Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes.  |  Schäfer, BW., et al. 1994. Nucleic Acids Res. 22: 4574-82. PMID: 7527137
9. The gene for PAX7, a member of the paired-box-containing genes, is localized on human chromosome arm 1p36.  |  Shapiro, DN., et al. 1993. Genomics. 17: 767-9. PMID: 7902328
10. Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.  |  Stapleton, P., et al. 1993. Nat Genet. 3: 292-8. PMID: 7981748
11. The genomic organization and the full coding region of the human PAX7 gene.  |  Vorobyov, E., et al. 1997. Genomics. 45: 168-74. PMID: 9339373
12. The role of Pax3 and Pax7 in development and cancer.  |  Mansouri, A. 1998. Crit Rev Oncog. 9: 141-9. PMID: 9973247

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pax-7 Antibody (PAX7) has 99 citations in a variety of scientific publications.

Primary antibodies like Anti-Pax-7 Antibody (PAX7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pax-7 Antibody (PAX7) Specifications

Alternate Product Name: Pax-7

Product Clone Name: PAX7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 352-523

Epitope Target: Pax-7

Epitope Species: chicken

Product Reactivity/Detection: Pax-7

Species Reactivity/Detection: mouse, rat, human, avian

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 99 citations in various scientific publications

Available Conjugates/Forms for Pax-7 Antibody (PAX7): AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein