pan-cadherin Antibody (E-11): sc-515872
- pan-cadherin Antibody (E-11) is a mouse monoclonal IgG2b κ pan-cadherin antibody, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 804-829 within a C-terminal cytoplasmic domain of cadherin of human origin
- pan-cadherin Antibody (E-11) is recommended for detection of P-cadherin, N-cadherin, E-cadherin, K-cadherin, M-cadherin and R-cadherin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-pan-cadherin Antibody (E-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for pan-cadherin Antibody (E-11) for WB applications. These reagents are now offered in bundles with pan-cadherin Antibody (E-11) (see ordering information below).
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pan-cadherin Antibody (E-11) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect a broad range of cadherin proteins, including P-cadherin, N-cadherin, E-cadherin, K-cadherin, M-cadherin, and R-cadherin, by targeting an epitope within amino acids 804-829 of the C-terminal cytoplasmic domain of human cadherins. pan-cadherin monoclonal antibody (E-11) is essential for researchers studying cell-cell adhesion, tissue architecture, and morphogenesis, as cadherins are crucial calcium-dependent adhesion molecules that mediate homophilic binding between cells, thereby maintaining the structural integrity of tissues. The C-terminal cytoplasmic domains of cadherins interact with a variety of intracellular proteins, most notably β-catenin, α-catenin, and p120-catenin, which link cadherins to the actin cytoskeleton and are involved in the regulation of cell signaling pathways that control cell proliferation, differentiation, and migration. These interactions are vital for processes such as embryonic development, wound healing, and the maintenance of epithelial and endothelial barriers. Additionally, the disruption of cadherin-mediated adhesion is implicated in pathological conditions including cancer metastasis, where the loss of E-cadherin function can lead to increased cellular invasiveness and tumor progression. anti-pan-cadherin antibody (E-11) exhibits robust reactivity with cadherins from mouse, rat, and human origins, making pan-cadherin (E-11) antibody a versatile tool for various experimental applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and several Alexa Fluor® variants, pan-cadherin (E-11) monoclonal antibody provides flexibility to accommodate diverse research needs and detection methods.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
pan-cadherin Antibody (E-11) References:
- Pan-cadherin as a high level phenotypic biomarker for prostate cancer. | Wehbi, NK., et al. 2002. J Urol. 167: 2215-21. PMID: 11956481
- Localization of pan-cadherin immunoreactivity in adult rat tissues. | Filiz, S., et al. 2002. Cell Biol Int. 26: 985-91. PMID: 12468390
- Immunohistochemical analysis of neural cell adhesion molecule (N-CAM) and pan-cadherin in the small intestine of intrauterine growth-retarded newborn rats caused by maternal protein malnutrition. | Dalçik, C., et al. 2003. Acta Histochem. 105: 183-90. PMID: 12831170
- Localization of neural cell adhesion molecule and pan-cadherin immunoreactivity in intrauterine growth-retarded newborn rat kidneys. | Filiz, S., et al. 2003. Appl Immunohistochem Mol Morphol. 11: 352-8. PMID: 14663363
- Antibodies neutralizing Nogo-A increase pan-cadherin expression and motor recovery following spinal cord injury in rats. | Atalay, B., et al. 2007. Spinal Cord. 45: 780-6. PMID: 17724451
- Nogo-A inhibitory peptide (NEP1-40) increases pan-cadherin expression following mild cortical contusion injury in rats. | Atalay, B., et al. 2008. Turk Neurosurg. 18: 356-65. PMID: 19107681
- Broad spectrum pan-cadherin antibodies, reactive with the C-terminal 24 amino acid residues of N-cadherin. | Geiger, B., et al. 1990. J Cell Sci. 97 (Pt 4): 607-14. PMID: 2077036
- Modulation of pan-cadherin expression in alveolar epithelial cells of mini pigs with pulmonary fibrosis. | Kasper, M. and Müller, M. 1994. Acta Histochem. 96: 439-44. PMID: 7536378
- Immunoelectron characterisation of the inter-endothelial junctions of human term placenta. | Leach, L., et al. 1993. J Cell Sci. 104 (Pt 4): 1073-81. PMID: 8314892
- Expression of a candidate cadherin in T lymphocytes. | Cepek, KL., et al. 1996. Proc Natl Acad Sci U S A. 93: 6567-71. PMID: 8692857
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pan-cadherin Antibody (E-11) | sc-515872 | 200 µg/ml | $322.00 | |||
pan-cadherin Antibody (E-11): m-IgG Fc BP-HRP Bundle | sc-531541 | 200 µg Ab; 10 µg BP | $361.00 | |||
pan-cadherin Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-525256 | 200 µg Ab, 40 µg BP | $361.00 | |||
pan-cadherin Antibody (E-11): m-IgG2b BP-HRP Bundle | sc-550296 | 200 µg Ab; 10 µg BP | $361.00 | |||
pan-cadherin Antibody (E-11) AC | sc-515872 AC | 500 µg/ml, 25% agarose | $424.00 | |||
pan-cadherin Antibody (E-11) HRP | sc-515872 HRP | 200 µg/ml | $322.00 | |||
pan-cadherin Antibody (E-11) FITC | sc-515872 FITC | 200 µg/ml | $336.00 | |||
pan-cadherin Antibody (E-11) PE | sc-515872 PE | 200 µg/ml | $349.00 | |||
pan-cadherin Antibody (E-11) Alexa Fluor® 488 | sc-515872 AF488 | 200 µg/ml | $364.00 | |||
pan-cadherin Antibody (E-11) Alexa Fluor® 546 | sc-515872 AF546 | 200 µg/ml | $364.00 | |||
pan-cadherin Antibody (E-11) Alexa Fluor® 594 | sc-515872 AF594 | 200 µg/ml | $364.00 | |||
pan-cadherin Antibody (E-11) Alexa Fluor® 647 | sc-515872 AF647 | 200 µg/ml | $364.00 | |||
pan-cadherin Antibody (E-11) Alexa Fluor® 680 | sc-515872 AF680 | 200 µg/ml | $364.00 | |||
pan-cadherin Antibody (E-11) Alexa Fluor® 790 | sc-515872 AF790 | 200 µg/ml | $364.00 |