P504S Antibody (G-8): sc-514408

P504S Antibody (G-8) is a mouse monoclonal IgG2b antibody that detects P504S in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). P504S, also known as α-methylacyl-CoA racemase (AMACR), is an enzyme that plays a crucial role in the metabolism of branched-chain fatty acids and bile acid intermediates, localizing primarily to the peroxisome and mitochondrion. This enzyme is responsible for catalyzing the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are essential for subsequent degradation via peroxisomal β-oxidation. Proper functioning of P504S is vital, as mutations in the gene encoding AMACR can lead to significant metabolic disorders, including AMACR deficiency, which is characterized by elevated levels of pristanic acid and is associated with adult-onset sensory motor neuropathy, as well as congenital bile acid synthesis defect type 4 (CBAS4), marked by intrahepatic cholestasis and neonatal jaundice. Furthermore, P504S is notably overexpressed in prostate cancer, indicating its potential role in promoting cancer cell growth, making P504S a significant target for research in cancer biology. Anti-P504S antibody (G-8) is an invaluable tool for studying these critical biological processes and disease states.

The preferred P504S antibody is P504S Antibody (2A10F3): sc-81710.