p-SMC1α Antibody (43.Ser 966): sc-135784

p-SMC1α Antibody (43.Ser 966) is a mouse monoclonal IgG2b light chain antibody that detects p-SMC1α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). p-SMC1α plays a crucial role in cell cycle regulation, particularly during S-phase checkpoint, where phosphorylation occurs at Ser 966. This phosphorylation activates S-phase checkpoint, ensuring accurate DNA replication and repair before mitosis. Such regulation helps maintain genomic stability and prevents damaged DNA propagation, which could lead to various diseases, including cancer. Anti-p-SMC1α antibody (43.Ser 966) is widely utilized in research to study cell cycle regulation dynamics and chromosomal stability mechanisms, making p-SMC1α monoclonal antibody (43.Ser 966) an invaluable tool for scientists investigating cellular processes and potential therapeutic targets.

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p-SMC1α Antibody (43.Ser 966) References:

1. Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family.  |  Nishiwaki, T., et al. 1999. J Hum Genet. 44: 197-202. PMID: 10319587
2. Complete cDNA cloning, genomic organization, chromosomal assignment, functional characterization of the promoter, and expression of the murine Bamacan gene.  |  Ghiselli, G., et al. 1999. J Biol Chem. 274: 17384-93. PMID: 10358101
3. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.  |  Strunnikov, AV. and Jessberger, R. 1999. Eur J Biochem. 263: 6-13. PMID: 10429180
4. Overexpression of bamacan/SMC3 causes transformation.  |  Ghiselli, G. and Iozzo, RV. 2000. J Biol Chem. 275: 20235-8. PMID: 10801778
5. Identification and molecular characterization of the mammalian α-kleisin RAD21L.  |  Gutiérrez-Caballero, C., et al. 2011. Cell Cycle. 10: 1477-87. PMID: 21527826
6. Dynamics of cohesin subunits in grasshopper meiotic divisions.  |  Calvente, A., et al. 2013. Chromosoma. 122: 77-91. PMID: 23283389
7. SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage.  |  Biswas, U., et al. 2018. Curr Biol. 28: 249-261.e4. PMID: 29337080
8. The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes.  |  Rocques, PJ., et al. 1995. Hum Mol Genet. 4: 243-9. PMID: 7757074
9. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.  |  Strunnikov, AV., et al. 1993. J Cell Biol. 123: 1635-48. PMID: 8276886
10. Basement membrane abnormalities in human eyes with diabetic retinopathy.  |  Ljubimov, AV., et al. 1996. J Histochem Cytochem. 44: 1469-79. PMID: 8985139
11. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs.  |  Wu, RR. and Couchman, JR. 1997. J Cell Biol. 136: 433-44. PMID: 9015313
12. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.  |  Schmiesing, JA., et al. 1998. Proc Natl Acad Sci U S A. 95: 12906-11. PMID: 9789013

The preferred SMC1 antibody is SMC1 Antibody (C2M): sc-56776.