SMC1 Antibody (C2M): sc-56776

SMC1 Antibody (C2M) is a mouse monoclonal IgG1 kappa light chain antibody that detects SMC1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-SMC1 antibody (C2M) is available as a non-conjugated format. SMC1, a member of the structural maintenance of chromosomes (SMC) family, plays a crucial role in maintaining chromatid cohesion and ensuring proper chromosome condensation during mitosis, which is vital for accurate cell division and genomic stability. SMC1 forms a heterodimeric complex with SMC3, and together they are essential for the progression of cells through metaphase, functioning independently of the SMC2/SMC4 complex. SMC1 is ubiquitously expressed across various human tissues, including the thymus, testis, and colon, highlighting its fundamental role in cellular processes. Notably, SMC3, which interacts with SMC1, is primarily localized in the nucleus of colon cells but can also be found as a secreted proteoglycan in the testis and brain, where SMC3 is believed to contribute to basement membrane physiology through multiple glycosylation sites. SMC1′s interaction with other proteins in the SMC family underscores its importance in chromosomal dynamics and cellular integrity, making SMC1 (C2M) monoclonal antibody a valuable tool for researchers studying cell cycle regulation and chromosomal behavior.

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SMC1 Antibody (C2M) References:

1. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.  |  Strunnikov, AV. and Jessberger, R. 1999. Eur J Biochem. 263: 6-13. PMID: 10429180
2. Overexpression of bamacan/SMC3 causes transformation.  |  Ghiselli, G. and Iozzo, RV. 2000. J Biol Chem. 275: 20235-8. PMID: 10801778
3. Isolation and characterization of human NBL4, a gene involved in the beta-catenin/tcf signaling pathway.  |  Ishiguro, H., et al. 2000. Jpn J Cancer Res. 91: 597-603. PMID: 10874211
4. SMC1 coordinates DNA double-strand break repair pathways.  |  Schär, P., et al. 2004. Nucleic Acids Res. 32: 3921-9. PMID: 15280507
5. SMC1 promotes epithelial-mesenchymal transition in triple-negative breast cancer through upregulating Brachyury.  |  Li, K., et al. 2016. Oncol Rep. 35: 2405-12. PMID: 26781859
6. Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing.  |  Hatkevich, T., et al. 2019. PLoS Genet. 15: e1008412. PMID: 31609962
7. The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes.  |  Rocques, PJ., et al. 1995. Hum Mol Genet. 4: 243-9. PMID: 7757074
8. The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation.  |  Scholzen, T., et al. 1994. J Biol Chem. 269: 28270-81. PMID: 7961765
9. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.  |  Strunnikov, AV., et al. 1993. J Cell Biol. 123: 1635-48. PMID: 8276886
10. Basement membrane abnormalities in human eyes with diabetic retinopathy.  |  Ljubimov, AV., et al. 1996. J Histochem Cytochem. 44: 1469-79. PMID: 8985139
11. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs.  |  Wu, RR. and Couchman, JR. 1997. J Cell Biol. 136: 433-44. PMID: 9015313
12. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.  |  Schmiesing, JA., et al. 1998. Proc Natl Acad Sci U S A. 95: 12906-11. PMID: 9789013

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SMC1 Antibody (C2M) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SMC1 Antibody (C2M) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SMC1 Antibody (C2M) Specifications

Alternate Product Name: SMC1

Product Clone Name: C2M

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 402-894

Epitope Target: SMC1

Epitope Species: human

Product Reactivity/Detection: SMC1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SMC1 Antibody (C2M): N/A