p-Rb Antibody (B-8): sc-377541
- p-Rb Antibody (B-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against a short amino acid sequence containing phosphorylated Thr 356 of Rb of human origin
- recommended for detection of Thr 356 phosphorylated Rb of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p-Rb Antibody (B-8) for WB and IHC(P) applications. These reagents are now offered in bundles with p-Rb Antibody (B-8) (see ordering information below).
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SEE ALSO...
p-Rb Antibody (B-8) is a mouse monoclonal IgG2a antibody that detects retinoblastoma protein (Rb) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Rb antibody (B-8) plays a crucial role in studying Rb, which regulates cell cycle progression, differentiation, and apoptosis. Rb protein is primarily located in the nucleus, where Rb functions as a key tumor suppressor by controlling the transition from G1 phase to S phase of the cell cycle. Nuclear localization allows Rb to interact with transcription factors and other regulatory proteins that govern cell proliferation. Dysregulation of Rb localization can lead to uncontrolled cell division and contribute to tumorigenesis, particularly in cancers such as retinoblastoma. Rb phosphorylation state, influenced by various kinases, determines activity and localization, making Rb a critical focus for cancer research. Using Rb monoclonal antibody (B-8), researchers can gain insights into Rb function mechanisms and implications in cancer biology, ultimately aiding in the development of targeted therapies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Rb Antibody (B-8) | sc-377541 | 200 µg/ml | $322.00 | |||
p-Rb Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-538052 | 200 µg Ab; 10 µg BP | $361.00 | |||
p-Rb Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-535578 | 200 µg Ab; 40 µg BP | $361.00 | |||
p-Rb Antibody (B-8): m-IgG2a BP-HRP Bundle | sc-548190 | 200 µg Ab; 10 µg BP | $361.00 | |||
p-Rb (B-8) Neutralizing Peptide | sc-377541 P | 100 µg/0.5 ml | $69.00 |