p-Ras GAP Antibody (pY460.19A): sc-136481

p-Ras GAP Antibody (pY460.19A) is a mouse monoclonal IgG1 antibody raised against phosphorylated human Ras GAP, a critical regulator of Ras signaling pathways. Anti-p-Ras GAP antibody (pY460.19A) specifically recognizes Ras GAP when phosphorylated and demonstrates broad species cross-reactivity, detecting phosphorylated Ras GAP in mouse, rat, and human samples through Western blotting (WB) and immunoprecipitation (IP) applications. This phosphorylation-dependent regulation is central to Ras GAP′s sophisticated control over p21Ras activity. Ras GAP functions as a molecular switch by promoting GTP hydrolysis, converting p21Ras from its active GTP-bound state to an inactive GDP-bound state. This mechanism proves particularly crucial in preventing uncontrolled cell proliferation that could lead to cancer development. The significance of this regulatory pathway becomes especially evident in cancer biology, where mutations in p21Ras can bypass this control mechanism, leading to persistent signaling and tumor formation. The specific interaction between phosphorylated Ras GAP and p21Ras not only maintains cellular homeostasis but also presents a potential therapeutic target in Ras-driven cancers. Through these phosphorylation-dependent functions, p-Ras GAP (pY460.19A) antibody provides researchers with a valuable tool for investigating both normal signaling mechanisms and cancer biology pathways.

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p-Ras GAP Antibody (pY460.19A) References:

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The preferred Ras GAP antibody is Ras GAP Antibody (B4F8): sc-63.