OSC Antibody (G-6): sc-365129

OSC Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects OSC (Lanosterol synthase) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OSC is a 732 amino acid protein that plays a pivotal role in the biosynthesis of cholesterol, vitamin D, and steroid hormones by catalyzing the conversion of (S)-2,3 oxidosqualene to lanosterol, the first step in the terpene metabolism pathway. Lanosterol, a tetracyclic triterpenoid, is essential for the synthesis of all steroids, making OSC crucial for maintaining proper cholesterol levels and overall steroid function in the body. OSC′s importance is underscored by a high degree of conservation across species, with human OSC sharing 83% homology with its rat counterpart, indicating a fundamental role in cellular processes. Multiple isoforms of OSC, resulting from alternative splicing events, suggests a complex regulation of function, which may have implications in various physiological and pathological contexts. Anti-OSC antibody (G-6) is an invaluable tool for researchers studying cholesterol metabolism and steroidogenesis, providing insights into molecular mechanisms underlying these critical biological processes.

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OSC Antibody (G-6) References:

1. Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract.  |  Shen, X., et al. 2018. J Ophthalmol. 2018: 4125893. PMID: 30116630
2. Lanosterol Synthase Genetic Variants, Endogenous Ouabain, and Both Acute and Chronic Kidney Injury.  |  Iatrino, R., et al. 2019. Am J Kidney Dis. 73: 504-512. PMID: 30660405
3. Protective Effects of Lanosterol Synthase Up-Regulation in UV-B-Induced Oxidative Stress.  |  Hua, H., et al. 2019. Front Pharmacol. 10: 947. PMID: 31555133
4. Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation.  |  Hubler, Z., et al. 2021. Cell Chem Biol. 28: 866-875.e5. PMID: 33636107
5. Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2.  |  Yang, F., et al. 2022. J Invest Dermatol. 142: 2687-2694.e2. PMID: 35413293
6. Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.  |  Nguyen, TP., et al. 2023. Cell Chem Biol. 30: 214-229.e18. PMID: 36758549
7. Lanosterol synthase loss of function decreases the malignant phenotypes of HepG2 cells by deactivating the Src/MAPK signaling pathway.  |  Sun, X., et al. 2023. Oncol Lett. 26: 295. PMID: 37274468
8. Prenatal diagnosis of lanosterol synthase deficiency: Fetal ultrasound findings as a window on family genetics.  |  Matza Porges, S., et al. 2023. Eur J Med Genet. 66: 104825. PMID: 37659595
9. Lanosterol Synthase Prevents EMT During Lens Epithelial Fibrosis Via Regulating SREBP1.  |  Ma, P., et al. 2023. Invest Ophthalmol Vis Sci. 64: 12. PMID: 38079167
10. Lanosterol synthase deficiency promotes tumor progression by orchestrating PDL1-dependent tumor immunosuppressive microenvironment.  |  Gao, Y., et al. 2024. MedComm (2020). 5: e528. PMID: 38606362

The preferred OSC antibody is OSC Antibody (D-6): sc-514507.