Date published: 2026-5-7

1-800-457-3801

SCBT Portrait Logo
Seach Input

OSC Inhibitors

OSC Inhibitors refer to a class of compounds that inhibit the enzyme oxidosqualene cyclase (OSC), which is pivotal in the biosynthetic pathway leading to the production of various sterols, including cholesterol. The enzyme catalyzes the cyclization of 2,3-oxidosqualene to lanosterol, an early sterol precursor in the pathway. Inhibiting OSC can therefore modulate the levels of sterols and other downstream bioactive molecules within the organism. The structure of OSC inhibitors is often designed to mimic the transition state of the enzyme's natural substrate, thereby binding to the active site of OSC and preventing it from processing the oxidosqualene to lanosterol. This inhibition can be competitive, non-competitive, or uncompetitive depending on the inhibitor's mechanism of action and its interaction with the enzyme. The biochemical role of oxidosqualene cyclase makes OSC inhibitors a point of interest in studies of sterol biosynthesis and regulation. Their ability to intervene in the biosynthetic pathway provides a tool for exploring the intricacies of sterol metabolism and the enzyme's role within it. Research involving these inhibitors often focuses on the enzyme's structure, function, and its expression in various biological systems. The specificity and potency of OSC inhibitors are key characteristics that are assessed during their development. High specificity ensures that the inhibitor targets only OSC without affecting other enzymes in the pathway, while high potency allows the inhibitor to effectively impede the enzyme's activity even at low concentrations.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Aminoglutethimide

125-84-8sc-207280
sc-207280A
sc-207280B
sc-207280C
1 g
5 g
25 g
100 g
$42.00
$146.00
$541.00
$2060.00
2
(1)

Aminoglutethimide is an OSC inhibitor. It inhibits the conversion of squalene to lanosterol, disrupting sterol synthesis.

BIBB 515

156635-05-1sc-205221
sc-205221A
5 mg
10 mg
$72.00
$124.00
1
(0)

BIBB 515 functions as an effective organic semiconductor, showcasing remarkable charge transport properties due to its unique molecular architecture. The compound exhibits strong π-π stacking interactions, enhancing its conductivity and stability in thin-film applications. Its distinct electron affinity facilitates efficient exciton dissociation, while the tailored functional groups promote favorable intermolecular interactions. The material's high mobility and low trap density contribute to its superior performance in electronic devices.

Ro 48-8071

161582-11-2sc-205492
sc-205492A
5 mg
10 mg
$51.00
$128.00
2
(0)

Ro 48-8071 serves as a notable organic semiconductor characterized by its unique electron-donating properties and robust intermolecular interactions. The compound's architecture allows for efficient charge transfer, driven by its specific alignment of molecular orbitals. Its ability to form stable aggregates enhances its photophysical properties, while the presence of halide substituents influences reactivity and solubility, optimizing its performance in various electronic applications.

Terbinafine

91161-71-6sc-338609
100 mg
$560.00
1
(0)

Terbinafine is an antifungal agent in research that specifically targets the fungal OSC enzyme. It disrupts the synthesis of ergosterol, leading to the accumulation of squalene and subsequent cell membrane damage in fungi.

Ro 48-8071 fumarate

189197-69-1sc-215817
sc-215817A
10 mg
50 mg
$94.00
$411.00
(0)

Ro 48-8071 fumarate exhibits intriguing characteristics as an organic semiconductor, particularly through its distinctive molecular framework that facilitates strong π-π stacking interactions. This arrangement promotes enhanced charge mobility and stability, crucial for electronic applications. The compound's unique electronic structure allows for selective electron transport, while its solvation dynamics are influenced by the presence of functional groups, affecting its overall reactivity and performance in diverse environments.

Diosgenin

512-04-9sc-205652
sc-205652B
sc-205652A
5 g
25 g
100 g
$47.00
$131.00
$517.00
4
(1)

Diosgenin is a natural compound found in certain plants, including fenugreek and wild yam. It acts as an OSC inhibitor, interfering with the conversion of squalene to lanosterol.

Betulinic Acid

472-15-1sc-200132
sc-200132A
25 mg
100 mg
$117.00
$344.00
3
(1)

Betulinic acid is a naturally occurring triterpenoid found in many plant species, including birch trees. It acts as an OSC inhibitor, interfering with the biosynthesis of sterols.

Betulin

473-98-3sc-234016
1 g
$102.00
5
(1)

Betulin is a triterpenoid compound found in birch bark. It inhibits OSC activity, leading to a decrease in sterol synthesis.