Nup93 Antibody (F-2): sc-374400

Nup93 Antibody (F-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects Nup93 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Nup93 antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nup93, a key component of the nuclear pore complex (NPC), plays a vital role in mediating the transport of macromolecules between the nucleus and cytoplasm, which is essential for maintaining cellular function and homeostasis. Nup93 is predominantly localized to the nuclear side of the NPC, particularly in the basket terminal ring area, where Nup93 forms a complex with other nucleoporins such as Nup188, Nup53, and Nup205. This interaction is crucial for the stability and proper assembly of the NPC, ensuring efficient nucleocytoplasmic transport. Nup93 is characterized by a coiled-coil domain at its N-terminus and a C-terminal helical domain, which are important for its structural integrity and function. Proper functioning of Nup93 is essential for cell viability, as disruptions in Nup93 activity can lead to impaired nucleocytoplasmic transport and subsequent cellular dysfunction.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Nup93 Antibody (F-2) References:

1. The diverse roles of the Nup93/Nic96 complex proteins - structural scaffolds of the nuclear pore complex with additional cellular functions.  |  Vollmer, B. and Antonin, W. 2014. Biol Chem. 395: 515-28. PMID: 24572986
2. First Report of Recurrent Nephrotic Syndrome After Kidney Transplantation in a Patient With NUP93 Gene Mutations: A Case Report.  |  Seeman, T. and Vondrak, K. 2018. Transplant Proc. 50: 3954-3956. PMID: 30577294
3. Molecular assay for an intronic variant in NUP93 that causes steroid resistant nephrotic syndrome.  |  Rossanti, R., et al. 2019. J Hum Genet. 64: 673-679. PMID: 31015583
4. Expression of Nup93 is associated with the proliferation, migration and invasion capacity of cervical cancer cells.  |  Ouyang, X., et al. 2019. Acta Biochim Biophys Sin (Shanghai). 51: 1276-1285. PMID: 31774908
5. Molecular and structural analysis of central transport channel in complex with Nup93 of nuclear pore complex.  |  Sonawane, PJ., et al. 2020. Protein Sci. 29: 2510-2527. PMID: 33085133
6. Steroid-resistant nephrotic syndrome in infants caused by a novel compound heterozygous mutation of the NUP93: A CARE case report.  |  Zhao, B., et al. 2021. Medicine (Baltimore). 100: e24627. PMID: 33578576
7. Exploring the relevance of NUP93 variants in steroid-resistant nephrotic syndrome using next generation sequencing and a fly kidney model.  |  Bierzynska, A., et al. 2022. Pediatr Nephrol. 37: 2643-2656. PMID: 35211795
8. Collapsing Focal Segmental Glomerulosclerosis in Siblings With Compound Heterozygous Variants in NUP93 Expand the Spectrum of Kidney Phenotypes Associated With Nucleoporin Gene Mutations.  |  Cason, RK., et al. 2022. Front Pediatr. 10: 915174. PMID: 35874595
9. Insights into the role of Nup62 and Nup93 in assembling cytoplasmic ring and central transport channel of the nuclear pore complex.  |  Madheshiya, PK., et al. 2022. Mol Biol Cell. 33: ar139. PMID: 36222862
10. Steroid-Resistant Nephrotic Syndrome Caused by NUP93 Pathogenic Variants.  |  Wasilewska, A., et al. 2023. J Clin Med. 12: PMID: 37762751

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nup93 Antibody (F-2) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Nup93 Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nup93 Antibody (F-2) Specifications

Alternate Product Name: Nup93

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-300

Epitope Target: Nup93

Epitope Species: human

Product Reactivity/Detection: Nup93

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Nup93 Antibody (F-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Nup93 antibody is Nup93 Antibody (E-8): sc-374399.