NTR1 Antibody (B-12): sc-376958

NTR1 Antibody (B-12) is a mouse monoclonal IgM antibody that detects NTR1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NTR1 Antibody (B-12) is available in a non-conjugated form, providing flexibility for various experimental needs. The neurotensin receptor 1 (NTR1) plays a crucial role in mediating the physiological effects of neurotensin, a neuropeptide involved in numerous central and peripheral processes. NTR1 is primarily located in the central nervous system, particularly in regions associated with pain modulation, appetite regulation, and cardiovascular control, making NTR1 essential for understanding neuropeptide signaling pathways. NTR1 activation can lead to a cascade of intracellular events, influencing the release of other signaling molecules and contributing to the regulation of blood pressure, glucose metabolism, and pain perception. Additionally, NTR1 interacts with various G proteins, including Gq, Gi/o, and Gs, which further underscores NTR1′s importance in diverse physiological responses. NTR1′s ability to couple with these G proteins highlights NTR1′s potential as a therapeutic target for conditions such as obesity, diabetes, and chronic pain, emphasizing NTR1′s relevance in both basic research and clinical applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

NTR1 Antibody (B-12) References:

1. Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive.  |  Buhler, AV., et al. 2005. Pain. 114: 285-94. PMID: 15733655
2. Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2.  |  Tsai, RT., et al. 2005. Genes Dev. 19: 2991-3003. PMID: 16357217
3. Dynamic interactions of Ntr1-Ntr2 with Prp43 and with U5 govern the recruitment of Prp43 to mediate spliceosome disassembly.  |  Tsai, RT., et al. 2007. Mol Cell Biol. 27: 8027-37. PMID: 17893323
4. Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.  |  Peddibhotla, S., et al. 2013. ACS Med Chem Lett. 4: 846-851. PMID: 24611085
5. NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/β-catenin signaling pathway in hepatocellular carcinoma.  |  Ye, Y., et al. 2016. Oncotarget. 7: 70303-70322. PMID: 27611941
6. Investigation of the Biological Impact of Charge Distribution on a NTR1-Targeted Peptide.  |  Jia, Y., et al. 2016. Bioconjug Chem. 27: 2658-2668. PMID: 27661393
7. Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2.  |  Fourmann, JB., et al. 2017. Nucleic Acids Res. 45: 4068-4080. PMID: 27923990
8. Cwc23 is a component of the NTR complex and functions to stabilize Ntr1 and facilitate disassembly of spliceosome intermediates.  |  Su, YL., et al. 2018. Nucleic Acids Res. 46: 3764-3773. PMID: 29390077
9. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.  |  Pinkerton, AB., et al. 2019. J Med Chem. 62: 8357-8363. PMID: 31390201
10. Mutagenesis and modeling of the neurotensin receptor NTR1. Identification of residues that are critical for binding SR 48692, a nonpeptide neurotensin antagonist.  |  Labbé-Jullié, C., et al. 1998. J Biol Chem. 273: 16351-7. PMID: 9632698

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NTR1 Antibody (B-12) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-NTR1 Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NTR1 Antibody (B-12) Specifications

Alternate Product Name: NTR1

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 389-417

Epitope Target: NTR1

Epitope Species: human

Product Reactivity/Detection: NTR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for NTR1 Antibody (B-12): P: Blocking Peptide

The preferred NTR1 antibody is NTR1 Antibody (B-9): sc-374492.