Notch1 Antibody (C-10): sc-373891
- Notch1 Antibody (C-10) is a mouse monoclonal IgG2b κ, cited in 26 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2433-2467 near the C-terminus of Notch 1 of human origin
- Anti-Notch1 Antibody (C-10) is recommended for detection of Notch 1 precursor, mature Notch 1, Notch 1 NEXT and Notch 1 NICD of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- Anti-Notch1 Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Notch1 Antibody (C-10) for WB applications. These reagents are now offered in bundles with Notch1 Antibody (C-10) (see ordering information below).
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Notch 1 Antibody (C-10) is a mouse monoclonal IgG2b kappa light chain antibody developed to detect human Notch1, also known as Neurogenic locus notch homolog protein 1. Notch1 monoclonal antibody (C-10) targets an epitope between amino acids 2433-2467 near the C-terminus of Notch1, ensuring precise recognition of the Notch1 precursor, mature Notch1, Notch1 NEXT, and Notch1 NICD forms across multiple species, including mouse, rat, human, and equine, in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Notch1 is a transmembrane receptor integral to cell fate determination during development and tissue homeostasis. Post-translational modifications (PTMs) of Notch1, such as glycosylation, phosphorylation, and ubiquitination, are crucial for function. Glycosylation of the extracellular domain influences ligand binding and receptor activation, while phosphorylation and ubiquitination of the intracellular domain regulate stability and degradation, thereby modulating signal transduction. Dysregulation of these PTMs can lead to aberrant Notch1 signaling, contributing to various pathologies, including cancers and developmental disorders. Anti-Notch1 antibody (C-10) is available in non-conjugated form and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, catering to diverse experimental needs. Manufactured under stringent quality controls, Notch1 (C-10) antibody ensures high specificity and reliability, making this tool indispensable for researchers investigating Notch1′s role in development, disease, and the impact of post-translational modifications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Notch1 Antibody (C-10) | sc-373891 | 200 µg/ml | $322.00 | |||
Notch1 Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-529598 | 200 µg Ab; 10 µg BP | $361.00 | |||
Notch1 Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-522544 | 200 µg Ab, 40 µg BP | $361.00 | |||
Notch1 Antibody (C-10): m-IgG2b BP-HRP Bundle | sc-550130 | 200 µg Ab; 10 µg BP | $361.00 | |||
Notch1 Antibody (C-10) AC | sc-373891 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Notch1 Antibody (C-10) HRP | sc-373891 HRP | 200 µg/ml | $322.00 | |||
Notch1 Antibody (C-10) FITC | sc-373891 FITC | 200 µg/ml | $336.00 | |||
Notch1 Antibody (C-10) PE | sc-373891 PE | 200 µg/ml | $349.00 | |||
Notch1 Antibody (C-10) Alexa Fluor® 488 | sc-373891 AF488 | 200 µg/ml | $364.00 | |||
Notch1 Antibody (C-10) Alexa Fluor® 546 | sc-373891 AF546 | 200 µg/ml | $364.00 | |||
Notch1 Antibody (C-10) Alexa Fluor® 594 | sc-373891 AF594 | 200 µg/ml | $364.00 | |||
Notch1 Antibody (C-10) Alexa Fluor® 647 | sc-373891 AF647 | 200 µg/ml | $364.00 | |||
Notch1 Antibody (C-10) Alexa Fluor® 680 | sc-373891 AF680 | 200 µg/ml | $364.00 | |||
Notch1 Antibody (C-10) Alexa Fluor® 790 | sc-373891 AF790 | 200 µg/ml | $364.00 | |||
Notch1 (C-10) Neutralizing Peptide | sc-373891 P | 100 µg/0.5 ml | $69.00 |