NOD1 Antibody (C-9): sc-377111
- NOD1 Antibody (C-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 715-890 mapping near the C-terminus of NOD1 of human origin
- recommended for detection of NOD1 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NOD1 Antibody (C-9) for WB applications. These reagents are now offered in bundles with NOD1 Antibody (C-9) (see ordering information below).
NOD1 Antibody (C-9) is a mouse monoclonal IgG1 antibody that detects NOD1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NOD1 plays a crucial role in the innate immune response by recognizing specific bacterial components, which is vital for initiating an appropriate immune reaction. NOD1 is primarily located in the cytoplasm of immune cells, where NOD1 acts as a sensor for bacterial peptidoglycans, leading to the activation of signaling pathways that promote inflammation and the production of pro-inflammatory cytokines. NOD1′s ability to detect pathogens and trigger immune responses underscores NOD1′s importance in maintaining host defense against infections. Furthermore, NOD1 interacts with various proteins, including the caspase recruitment domain-containing kinase RICK, which is essential for downstream signaling that activates NF-kB, a key transcription factor in immune responses. Anti-NOD1 antibody (C-9) is an invaluable tool for researchers studying the mechanisms of immune signaling and NOD1′s role in various diseases, including infections and inflammatory disorders.
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NOD1 Antibody (C-9) References:
- NOD1 and NOD2 signalling links ER stress with inflammation. | Keestra-Gounder, AM., et al. 2016. Nature. 532: 394-7. PMID: 27007849
- Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective. | D'Ambrosio, EA., et al. 2019. Bioorg Med Chem Lett. 29: 1153-1161. PMID: 30890292
- Palmitoylation of NOD1 and NOD2 is required for bacterial sensing. | Lu, Y., et al. 2019. Science. 366: 460-467. PMID: 31649195
- NOD1 and NOD2 in inflammatory and infectious diseases. | Trindade, BC. and Chen, GY. 2020. Immunol Rev. 297: 139-161. PMID: 32677123
- NOD1 in the interplay between microbiota and gastrointestinal immune adaptations. | Fernández-García, V., et al. 2021. Pharmacol Res. 171: 105775. PMID: 34273489
- Identification of Novel Endogenous NOD Ligands: Quantitative Analysis of Binding Affinities of NOD1 or NOD2 with Sphingosine-1-Phosphate Using Microscale Thermophoresis. | Pei, G. 2022. Methods Mol Biol. 2523: 151-160. PMID: 35759196
- Activation of NOD1 and NOD2 in the development of liver injury and cancer. | Omaru, N., et al. 2022. Front Immunol. 13: 1004439. PMID: 36268029
- NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-ĸB-independent manner. | Hezinger, L., et al. 2023. FEBS J. 290: 5295-5312. PMID: 37488967
- Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1. | Ma, W., et al. 2024. Protein Cell. 15: 419-440. PMID: 38437016
- Activation of NOD1 on tumor-associated macrophages augments CD8+ T cell-mediated antitumor immunity in hepatocellular carcinoma. | Zhang, F., et al. 2024. Sci Adv. 10: eadp8266. PMID: 39356756
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOD1 Antibody (C-9) | sc-377111 | 200 µg/ml | $316.00 | |||
NOD1 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-538021 | 200 µg Ab; 10 µg BP | $354.00 | |||
NOD1 Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-535541 | 200 µg Ab; 40 µg BP | $354.00 | |||
NOD1 Antibody (C-9): m-IgG1 BP-HRP Bundle | sc-545488 | 200 µg Ab; 20 µg BP | $354.00 |