NK-1R Antibody (F-3): sc-514453

NK-1R Antibody (F-3) is a mouse monoclonal IgG2b antibody that detects NK-1R in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NK-1R, also known as the substance P receptor, is a critical member of the tachykinin receptor family, which includes NK-2 and NK-3 receptors, and plays a significant role in various physiological processes. NK-1R is primarily located in the central nervous system, particularly in the dorsal horn of the spinal cord, where NK-1R is expressed in a high proportion of spinothalamic and spinobranchial neurons. NK-1R localization is crucial as NK-1R is involved in nociceptive transmission, influencing pain perception and the modulation of chronic neuropathic and inflammatory pain. Furthermore, NK-1R′s interaction with tachykinin peptides, such as substance P, substance K, and neuromedin K, highlights NK-1R′s importance in mediating responses related to anxiety and depression. Notably, ligand-induced internalization of NK-1R into early endosomes can lead to a depletion of cell surface receptors, which may serve as a down-regulation mechanism in response to substance P, thereby affecting NK-1R′s availability and function in pain signaling pathways.

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NK-1R Antibody (F-3) References:

1. Relationship between overexpression of NK-1R, NK-2R and intestinal mucosal damage in acute necrotizing pancreatitis.  |  Shi, X., et al. 2003. World J Gastroenterol. 9: 160-4. PMID: 12508374
2. LIF upregulates expression of NK-1R in NHBE cells.  |  Hu, CP., et al. 2006. Mediators Inflamm. 2006: 84829. PMID: 17392578
3. Analysis on correlation between SP and NK-1R and intranasal mucosal contact point headache.  |  Zhao, G., et al. 2016. Acta Otolaryngol. 136: 522-7. PMID: 26817501
4. The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders.  |  Johnson, MB., et al. 2016. Front Cell Neurosci. 10: 296. PMID: 28101005
5. MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells.  |  Huang, C., et al. 2018. Theranostics. 8: 3074-3086. PMID: 29896303
6. Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.  |  Liu, X., et al. 2019. Artif Cells Nanomed Biotechnol. 47: 1628-1634. PMID: 31010320
7. The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages.  |  Zhao, XN., et al. 2020. Drug Des Devel Ther. 14: 1943-1952. PMID: 32546961
8. Significance of the Overexpression of Substance P and Its Receptor NK-1R in Head and Neck Carcinogenesis: A Systematic Review and Meta-Analysis.  |  González-Moles, MÁ., et al. 2021. Cancers (Basel). 13: PMID: 33802704
9. Dramatic Effect of Botulinum Toxin Type A on Hypertrophic Scar: A Promising Therapeutic Drug and Its Mechanism Through the SP-NK1R Pathway in Cutaneous Neurogenic Inflammation.  |  Zhang, S., et al. 2022. Front Med (Lausanne). 9: 820817. PMID: 35308522
10. Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage.  |  Jin, P., et al. 2022. J Neuroinflammation. 19: 198. PMID: 35922848

The preferred NK-1R antibody is NK-1R Antibody (D-11): sc-365091.