Nix Antibody (B-1): sc-271076

Nix Antibody (B-1) is a mouse monoclonal IgG2a kappa light chain antibody designed to target the Nix protein, also known as BNIP3L. anti-Nix antibody (B-1) is raised against amino acids 1-219, representing the full-length human Nix protein, ensuring precise and reliable binding. Nix is a pro-apoptotic member of the Bcl-2 family, predominantly localized to the mitochondria, where it plays a crucial role in regulating programmed cell death and maintaining mitochondrial integrity. The mitochondrial localization of Nix is essential for its function, as it interacts with key proteins such as Bcl-xL, effectively neutralizing their anti-apoptotic activity to promote apoptosis. Additionally, Nix interacts with other proteins involved in autophagy, including Beclin-1, linking apoptotic and autophagic pathways to facilitate cellular homeostasis and the removal of damaged mitochondria. Nix monoclonal antibody (B-1) exhibits broad species reactivity, effectively recognizing Nix proteins from mouse, rat, and human origins across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). This versatility makes Nix (B-1) antibody an invaluable tool for researchers studying apoptosis, mitochondrial dynamics, and related signaling mechanisms in different model organisms. Furthermore, anti-Nix antibody (B-1) detection capabilities in multiple assay formats enhances research utility in both basic research and clinical investigations. By enabling accurate detection and analysis of Nix and its interactions, Nix (B-1) monoclonal antibody supports advancements in understanding the molecular pathways of cell death and their implications in diseases such as cancer and neurodegenerative disorders.

The preferred BNIP-3 antibody is BNIP-3 Antibody (ANa40): sc-56167.