Nectin 2 Antibody (D-11): sc-373715

Nectin 2 Antibody (D-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Nectin 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Nectin 2 antibody (D-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nectin 2, also known as poliovirus receptor-related protein 2 (PRR2) or HveB, is a crucial member of the nectin family, playing a significant role in cell adhesion and communication. Nectin 2 protein is predominantly located at the cell membrane, facilitating homophilic interactions between adjacent cells and contributing to tight junction formation and tissue integrity maintenance. Proper localization of Nectin 2 protein is essential for mediating entry of certain herpesviruses, such as herpes simplex virus types 1 and 2, into host cells. Nectin 2 protein interacts with PDZ domain of afadin to organize actin cytoskeleton, maintaining cellular architecture and signaling pathways. Two splicing variants, Nectin 2α and Nectin 2δ, exhibit unique cytoplasmic regions that may influence specific roles in cellular processes. Nectin 2 monoclonal antibody (D-11) serves as an invaluable tool for researchers studying cell adhesion mechanisms, viral entry pathways, and cellular interactions in various biological contexts.

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Nectin 2 Antibody (D-11) References:

1. The herpes simplex virus JMP mutant enters receptor-negative J cells through a novel pathway independent of the known receptors nectin1, HveA, and nectin2.  |  Cocchi, F., et al. 2004. J Virol. 78: 4720-9. PMID: 15078954
2. Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction.  |  Pende, D., et al. 2006. Blood. 107: 2030-6. PMID: 16304049
3. Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process.  |  Bachelet, I., et al. 2006. J Biol Chem. 281: 27190-6. PMID: 16831868
4. [Preparation and characterization of monoclonal antibodies against human CD112 (Nectin2/PRR2)].  |  Deng, HP., et al. 2007. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 23: 356-8. PMID: 17428395
5. The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors.  |  Dekanić, A., et al. 2023. Pathol Res Pract. 244: 154416. PMID: 36989846
6. Diagnostic and Prognostic Roles of Urine Nectin-2 and Nectin-4 in Human Bladder Cancer.  |  Miyake, M., et al. 2023. Cancers (Basel). 15: PMID: 37174031
7. Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy.  |  Wienke, J., et al. 2024. Cancer Cell. 42: 283-300.e8. PMID: 38181797
8. Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2.  |  Hu, S., et al. 2024. Structure. 32: 918-929.e4. PMID: 38626767
9. Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling.  |  Agorku, DJ., et al. 2024. Cancer Lett. 595: 216985. PMID: 38821255
10. Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.  |  Luo, H., et al. 2024. J Exp Clin Cancer Res. 43: 258. PMID: 39261943

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nectin 2 Antibody (D-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Nectin 2 Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nectin 2 Antibody (D-11) Specifications

Alternate Product Name: Nectin 2

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 23-56

Epitope Target: Nectin 2

Epitope Species: human

Product Reactivity/Detection: Nectin 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Nectin 2 Antibody (D-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Nectin 2 antibody is Nectin 2 Antibody (E-1): sc-271236.