NE-dlg Antibody (A-1): sc-514889

NE-dlg Antibody (A-1) is a mouse monoclonal IgG2b antibody that detects NE-dlg in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NE-dlg, a member of the membrane-associated guanylate kinase (MAGUK) family, plays a crucial role in synaptic signaling and cellular architecture by localizing at the membrane-cytoskeleton interface. This localization facilitates the assembly of protein complexes essential for maintaining synaptic integrity and mediating intracellular signaling pathways. The structural features of NE-dlg, including distinct PDZ, SH3, and guanylate kinase domains, enable interactions with various signaling molecules, influencing processes such as cell growth and differentiation. NE-dlg has been shown to interact with the tumor suppressor protein APC, suggesting involvement in growth regulation and highlighting potential significance in cancer biology. With insights into synaptic function and cellular signaling, anti-NE-dlg antibody (A-1) serves as an invaluable tool for researchers studying neurobiology and tumor suppression mechanisms.

The preferred NE-dlg antibody is NE-dlg Antibody (B-3): sc-514720.