NE-dlg Antibody (B-3): sc-514720
- NE-dlg Antibody (B-3) is a mouse monoclonal IgG2a κ NE-dlg antibody provided at 200 µg/ml
- raised against amino acids 1-132 mapping at the N-terminus of NE-dlg of human origin
- NE-dlg Antibody (B-3) is recommended for detection of NE-dlg of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NE-dlg Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of NE-dlg (B-3): sc-514720.
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NE-dlg Antibody (B-3) for WB applications. These reagents are now offered in bundles with NE-dlg Antibody (B-3) (see ordering information below).
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NE-dlg Antibody (B-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects NE-dlg of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NE-dlg (B-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NE-dlg, a member of the membrane-associated guanylate kinase (MAGUK) family, plays a crucial role in synaptic signaling and cellular communication, particularly in the nervous and endocrine systems. NE-dlg localization at the membrane-cytoskeleton interface is vital for maintaining structural integrity of synapses and facilitating intracellular signaling pathways. Several distinct domains are essential for NE-dlg function, including PDZ, SH3, and guanylate kinase-like domains, which enable interactions with various signaling molecules and scaffolding proteins. NE-dlg interactions with tumor suppressor protein APC suggest involvement in cell growth and differentiation regulation. This multifaceted role underscores NE-dlg importance in both normal cellular function and potential pathological conditions, making anti-NE-dlg antibody (B-3) an invaluable tool for researchers studying synaptic dynamics and related signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NE-dlg Antibody (B-3) References:
- Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution. | Stehle, T. and Schulz, GE. 1992. J Mol Biol. 224: 1127-41. PMID: 1314905
- The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. | Cho, KO., et al. 1992. Neuron. 9: 929-42. PMID: 1419001
- Tumor-suppressor genes of Drosophila melanogaster. | Gateff, E. and Mechler, BM. 1989. Crit Rev Oncog. 1: 221-45. PMID: 2518684
- Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. | Müller, BM., et al. 1995. J Neurosci. 15: 2354-66. PMID: 7891172
- Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. | Lue, RA., et al. 1994. Proc Natl Acad Sci U S A. 91: 9818-22. PMID: 7937897
- ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions. | Woods, DF. and Bryant, PJ. 1993. Mech Dev. 44: 85-9. PMID: 8155583
- Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. | Matsumine, A., et al. 1996. Science. 272: 1020-3. PMID: 8638125
- Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein. | Makino, K., et al. 1997. Oncogene. 14: 2425-33. PMID: 9188857
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NE-dlg Antibody (B-3) | sc-514720 | 200 µg/ml | $316.00 | |||
NE-dlg Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-524827 | 200 µg Ab, 40 µg BP | $354.00 | |||
NE-dlg Antibody (B-3): m-IgG2a BP-HRP Bundle | sc-546175 | 200 µg Ab; 10 µg BP | $354.00 | |||
NE-dlg Antibody (B-3) AC | sc-514720 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NE-dlg Antibody (B-3) HRP | sc-514720 HRP | 200 µg/ml | $316.00 | |||
NE-dlg Antibody (B-3) FITC | sc-514720 FITC | 200 µg/ml | $330.00 | |||
NE-dlg Antibody (B-3) PE | sc-514720 PE | 200 µg/ml | $343.00 | |||
NE-dlg Antibody (B-3) Alexa Fluor® 488 | sc-514720 AF488 | 200 µg/ml | $357.00 | |||
NE-dlg Antibody (B-3) Alexa Fluor® 546 | sc-514720 AF546 | 200 µg/ml | $357.00 | |||
NE-dlg Antibody (B-3) Alexa Fluor® 594 | sc-514720 AF594 | 200 µg/ml | $357.00 | |||
NE-dlg Antibody (B-3) Alexa Fluor® 647 | sc-514720 AF647 | 200 µg/ml | $357.00 | |||
NE-dlg Antibody (B-3) Alexa Fluor® 680 | sc-514720 AF680 | 200 µg/ml | $357.00 | |||
NE-dlg Antibody (B-3) Alexa Fluor® 790 | sc-514720 AF790 | 200 µg/ml | $357.00 |