NE-dlg activators refer to a selection of chemical compounds that have been identified or designed to augment the functionality or expression of the NE-dlg protein. NE-dlg, part of the DLG (Discs large) family of proteins, plays critical roles in various cellular events, spanning from cell polarity and proliferation to synaptic signaling. Its significance is emphasized by its interactions with numerous cellular partners and its involvement in diverse signaling cascades. Given the multifaceted nature of NE-dlg in cellular physiology, the precise modulation of its activity using chemical activators becomes an area of substantial interest.
Chemicals that fall under the classification of NE-dlg activators typically operate through distinct mechanisms to amplify the activity or expression of NE-dlg. Some activators might enhance the protein's direct interactions with its cellular partners, reinforcing its role in signal transduction pathways. Others might act by preserving the protein's stability within the cellular milieu, ensuring its enduring presence and consequent functionality. Additionally, certain compounds might stimulate the transcription or translation of the NE-dlg gene, leading to a surge in protein levels within the cell. On a molecular spectrum, these activators might achieve their function either by directly binding to NE-dlg, altering its structure to a more active configuration, or by modulating cellular pathways that supervise NE-dlg's expression or activity. A comprehensive grasp of NE-dlg activators not only deepens our understanding of cellular signaling dynamics but also paves the way for more informed explorations in the realm of cellular biology.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase (HDAC) inhibitor, it can promote a more relaxed chromatin state. This can enhance the transcription of genes, potentially including NE-DLG if its expression is regulated by histone acetylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By increasing cellular cAMP levels, Forskolin activates the cAMP-dependent protein kinase A (PKA) pathway. If NE-DLG is part of a signaling cascade modulated by PKA, its activity or expression might be influenced. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
As an activator of protein kinase C (PKC), PMA might affect proteins downstream of PKC signaling, potentially impacting NE-DLG expression or activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, it modulates a plethora of cellular responses, and might influence NE-DLG expression in a context-dependent manner. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol from green tea, known to modulate multiple cellular pathways, potentially influencing NE-DLG expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
An inducer of phase II detoxification enzymes, it might influence cellular stress responses, potentially impacting NE-DLG expression. |