NDRG2 Antibody (E-4): sc-365080
- NDRG2 Antibody (E-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 223-259 within an internal region of NDRG2 of human origin
- recommended for detection of NDRG2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NDRG2 Antibody (E-4) for WB applications. These reagents are now offered in bundles with NDRG2 Antibody (E-4) (see ordering information below).
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NDRG2 Antibody (E-4) is a mouse monoclonal IgG1 antibody that detects NDRG2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NDRG2, also known as SYLD, is a 371 amino acid protein that plays a crucial role in neuronal differentiation and outgrowth, localizing primarily in the cytoplasm and perinuclear region of neurons. NDRG2 expression is notably high in tissues such as the heart, brain, dendritic cells, salivary glands, and skeletal muscle, while lower levels are observed in the liver and kidney. NDRG2′s importance extends to potential involvement in tumor suppression, as NDRG2 expression is downregulated in various carcinomas, including liver and pancreatic cancers, as well as meningioma. Furthermore, NDRG2 has been implicated in the pathology of Alzheimer′s disease, being present in brain lesions of affected patients, which suggests a link to disease progression. Notably, NDRG2 undergoes alternative splicing, resulting in five distinct isoforms, which may contribute to diverse functional roles in cellular processes. Anti-NDRG2 antibody (E-4) is an essential tool for researchers investigating the multifaceted roles of this protein in health and disease.
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NDRG2 Antibody (E-4) References:
- NDRG2 controls COX-2/PGE₂-mediated breast cancer cell migration and invasion. | Kim, MJ., et al. 2014. Mol Cells. 37: 759-65. PMID: 25256221
- The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β. | Ichikawa, T., et al. 2015. Cell Signal. 27: 2087-98. PMID: 26208882
- Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer. | Hu, W., et al. 2016. Oncotarget. 7: 209-23. PMID: 26506239
- NDRG2 knockdown promotes fibrosis in renal tubular epithelial cells through TGF-β1/Smad3 pathway. | Jin, Z., et al. 2017. Cell Tissue Res. 369: 603-610. PMID: 28646304
- NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia. | Yang, YQ., et al. 2018. BMC Cancer. 18: 1009. PMID: 30348117
- Expression of NDRG2 in Human Colorectal Cancer and its Association with Prognosis. | Chen, W., et al. 2019. J Cancer. 10: 3373-3380. PMID: 31293640
- The regulation of NDRG2 expression during ATLL development after HTLV-1 infection. | Ichikawa, T., et al. 2019. Biochim Biophys Acta Mol Basis Dis. 1865: 2633-2646. PMID: 31295529
- Astrocyte-specific NDRG2 gene: functions in the brain and neurological diseases. | Li, X., et al. 2020. Cell Mol Life Sci. 77: 2461-2472. PMID: 31834421
- NDRG2 regulates the formation of reactive astrocyte-derived progenitor cells via Notch signaling pathway after brain traumatic injury in rats. | Zhang, Q., et al. 2023. Front Mol Neurosci. 16: 1149683. PMID: 37082656
- Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2low Adult T-Cell Leukemia/Lymphoma. | Ichikawa, T., et al. 2024. Int J Mol Sci. 25: PMID: 38474089
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDRG2 Antibody (E-4) | sc-365080 | 200 µg/ml | $322.00 | |||
NDRG2 Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-537773 | 200 µg Ab; 10 µg BP | $361.00 | |||
NDRG2 Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-535147 | 200 µg Ab; 40 µg BP | $361.00 | |||
NDRG2 Antibody (E-4): m-IgG1 BP-HRP Bundle | sc-545343 | 200 µg Ab; 20 µg BP | $361.00 | |||
NDRG2 (E-4) Neutralizing Peptide | sc-365080 P | 100 µg/0.5 ml | $69.00 |