NCAM-L1 Antibody (2Q789): sc-71653
- NCAM-L1 Antibody (2Q789) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against fetal brain of human origin
- recommended for detection of NCAM-L1 of mouse, rat and human origin by WB and IP
- See NCAM-L1 (D-5): sc-374046 for NCAM-L1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NCAM-L1 Antibody (2Q789) for WB applications. These reagents are now offered in bundles with NCAM-L1 Antibody (2Q789) (see ordering information below).
NCAM-L1 Antibody (2Q789) is a mouse monoclonal IgG1 antibody that detects NCAM-L1 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. NCAM-L1, also known as CD171, is a crucial cell adhesion molecule that plays a significant role in axon guidance and cell migration within the nervous system. NCAM-L1 expression is vital for proper neuronal development and function, facilitating interactions between neurons and their environment, influencing processes such as synaptic plasticity and neural network formation. NCAM-L1 is also implicated in various human tumors, including neuroblastomas and rhabdomyosarcomas, where NCAM-L1 may enhance tumor progression by promoting cell adhesion and migration. The ability of NCAM-L1 to mediate these interactions underscores NCAM-L1′s importance not only in normal physiological processes but also in pathological conditions, making anti-NCAM-L1 antibody (2Q789) an essential tool for researchers studying both developmental biology and cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NCAM-L1 Antibody (2Q789) References:
- A potential role for the plasmin(ogen) system in the posttranslational cleavage of the neural cell adhesion molecule L1. | Nayeem, N., et al. 1999. J Cell Sci. 112 (Pt 24): 4739-49. PMID: 10574721
- Long-term potentiation in mice lacking the neural cell adhesion molecule L1. | Bliss, T., et al. Curr Biol. 10: 1607-10. PMID: 11137015
- Single chain Fv antibodies against neural cell adhesion molecule L1 trigger L1 functions in cultured neurons. | Dong, L., et al. 2003. Mol Cell Neurosci. 22: 234-47. PMID: 12676533
- Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X-linked hydrocephalus. | Rosenthal, A., et al. 1992. Nat Genet. 2: 107-12. PMID: 1303258
- Cellular localization of the neural cell adhesion molecule L1 in adult rat neuroendocrine and endocrine tissues: comparisons with NCAM. | Grant, NJ., et al. 1992. J Comp Neurol. 325: 548-58. PMID: 1469114
- Antibody fragments directed against different portions of the human neural cell adhesion molecule L1 act as inhibitors or activators of L1 function. | Wang, Y., et al. 2012. PLoS One. 7: e52404. PMID: 23272240
- Single chain fragment variable antibodies developed by using as target the 3rd fibronectin type III homologous repeat fragment of human neural cell adhesion molecule L1 promote cell migration and neuritogenesis. | Tang, DY., et al. 2015. Exp Cell Res. 330: 336-345. PMID: 25447207
- CD171 Multi-epitope peptide design based on immuno-informatics approach as a cancer vaccine candidate for glioblastoma. | Mohammadzadeh Hosseini Moghri, SAH., et al. 2023. J Biomol Struct Dyn. 41: 1028-1040. PMID: 36617427
- Impaired expression of neural cell adhesion molecule L1 in the extrinsic nerve fibers in Hirschsprung's disease. | Ikawa, H., et al. 1997. J Pediatr Surg. 32: 542-5. PMID: 9126750
- Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. | Cohen, NR., et al. 1998. Curr Biol. 8: 26-33. PMID: 9427628
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NCAM-L1 Antibody (2Q789) | sc-71653 | 200 µg/ml | $316.00 | |||
NCAM-L1 Antibody (2Q789): m-IgG Fc BP-HRP Bundle | sc-539387 | 200 µg Ab; 10 µg BP | $354.00 | |||
NCAM-L1 Antibody (2Q789): m-IgG1 BP-HRP Bundle | sc-541454 | 200 µg Ab; 20 µg BP | $354.00 |