myotubularin Antibody (F-1): sc-377309

myotubularin Antibody (F-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects myotubularin of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). myotubularin (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. myotubularin functions as a lipid phosphatase, specifically acting on phosphatidylinositol 3-monophosphate, which is vital for regulating the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. This regulation influences cellular processes such as growth, survival, and metabolism, which are essential for maintaining muscle function. Mutations in MTM1 are linked to X-linked recessive myotubular myopathy, a severe congenital muscular disorder characterized by profound hypotonia and muscle weakness, often resulting in early postnatal mortality. MTM1 is located in a critical region on the X chromosome and encodes a 603 amino-acid protein that is highly conserved across species. hMTMR2, which is also implicated in muscle and nerve disorders, highlights the interconnectedness of these proteins in cellular function and disease.

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myotubularin Antibody (F-1) References:

1. Germline mosaicism in X-linked myotubular myopathy.  |  Häne, BG., et al. 1999. Clin Genet. 56: 77-81. PMID: 10466421
2. Identification of novel mutations in the MTM1 gene causing severe and mild forms of X-linked myotubular myopathy.  |  Buj-Bello, A., et al. 1999. Hum Mutat. 14: 320-5. PMID: 10502779
3. Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway.  |  Blondeau, F., et al. 2000. Hum Mol Genet. 9: 2223-9. PMID: 11001925
4. The myotubularin family: from genetic disease to phosphoinositide metabolism.  |  Laporte, J., et al. 2001. Trends Genet. 17: 221-8. PMID: 11275328
5. New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.  |  Larabi, A., et al. 2020. Autophagy. 16: 38-51. PMID: 31286804
6. Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt.  |  Zhang, JL., et al. 2020. Cell Death Dis. 11: 140. PMID: 32080168
7. Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma.  |  Weidner, P., et al. 2020. Oncogenesis. 9: 59. PMID: 32522977
8. Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.  |  Weidner, P., et al. 2024. Cancer Lett. 588: 216783. PMID: 38462034
9. Recent advances of myotubularin-related (MTMR) protein family in cardiovascular diseases.  |  Wang, J., et al. 2024. Front Cardiovasc Med. 11: 1364604. PMID: 38529329
10. A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.  |  Laporte, J., et al. 1996. Nat Genet. 13: 175-82. PMID: 8640223
11. Comparative mapping on the mouse X chromosome defines a myotubular myopathy equivalent region.  |  de Gouyon, B., et al. 1996. Mamm Genome. 7: 575-9. PMID: 8678976
12. Mutations in the MTM1 gene implicated in X-linked myotubular myopathy. ENMC International Consortium on Myotubular Myopathy. European Neuro-Muscular Center.  |  Laporte, J., et al. 1997. Hum Mol Genet. 6: 1505-11. PMID: 9305655

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-myotubularin Antibody (F-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-myotubularin Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

myotubularin Antibody (F-1) Specifications

Alternate Product Name: myotubularin

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 21-57

Epitope Target: myotubularin

Epitope Species: human

Product Reactivity/Detection: myotubularin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for myotubularin Antibody (F-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin