MYBPC3 Antibody (G-7): sc-137237
- MYBPC3 Antibody (G-7) is a mouse monoclonal IgG1 κ, cited in 20 publications, provided at 200 µg/ml
- raised against amino acids 1-120 mapping at the N-terminus of MYBPC3 of human origin
- Anti-MYBPC3 Antibody (G-7) is recommended for detection of MYBPC3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MYBPC3 Antibody (G-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MYBPC3 Antibody (G-7) for WB and IHC(P) applications. These reagents are now offered in bundles with MYBPC3 Antibody (G-7) (see ordering information below).
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MYBPC3 Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects MYBPC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MYBPC3 (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MYBPC3, or myosin-binding protein C, cardiac, plays a crucial role in cardiac muscle contraction by interacting with myosin and actin filaments, thereby regulating the contractile function of the heart. MYBPC3 is predominantly located in the crossbridge-bearing zone of the A bands in vertebrate striated muscle, where MYBPC3 contributes to the structural integrity and function of the sarcomere. Proper localization of MYBPC3 ensures correct assembly of the thick filament and regulation of myosin ATPase activity, which is vital for muscle contraction. Dysregulation or mutations in MYBPC3 can lead to familial hypertrophic cardiomyopathy type 4 (CMH4), a genetic heart disorder characterized by abnormal thickening of the heart muscle, particularly affecting the interventricular septum, which can lead to serious complications. MYBPC3 is located on chromosome 11p11.2, highlighting MYBPC3′s significance in cardiac health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MYBPC3 Antibody (G-7) References:
- Effects of MYBPC3 loss-of-function mutations preceding hypertrophic cardiomyopathy. | Helms, AS., et al. 2020. JCI Insight. 5: PMID: 31877118
- Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations. | Pei, J., et al. 2021. Clin Epigenetics. 13: 61. PMID: 33757590
- Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy. | Suay-Corredera, C., et al. 2021. J Biol Chem. 297: 100854. PMID: 34097875
- Novel pathogenic variant of MYBPC3 responsible for hypertrophic cardiomyopathy. | Yang, X., et al. 2022. Cardiol Young. 32: 539-544. PMID: 34180388
- Myocardial Deformation Analysis in MYBPC3 and MYH7 Related Sarcomeric Hypertrophic Cardiomyopathy-The Graz Hypertrophic Cardiomyopathy Registry. | Höller, V., et al. 2021. Genes (Basel). 12: PMID: 34680864
- Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload. | Ramachandran, A., et al. 2023. J Cardiovasc Transl Res. 16: 828-841. PMID: 36877449
- A Promoter Deletion Confirms That MYBPC3 Haploinsufficiency Is Sufficient to Cause Hypertrophic Cardiomyopathy in Humans. | Hayesmoore, JBG., et al. 2024. Circ Genom Precis Med. 17: e004134. PMID: 38258577
- Generation of induced pluripotent stem cells from an individual with early onset and severe hypertrophic cardiomyopathy linked to MYBPC3: c.772G > A mutation. | Ribeiro, M., et al. 2024. Hum Cell. 37: 1205-1214. PMID: 38762696
- Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation. | Mori, H., et al. 2024. Sci Rep. 14: 15422. PMID: 38965264
- MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids. | Desai, D., et al. 2024. Cells. 13: PMID: 39594661
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYBPC3 Antibody (G-7) | sc-137237 | 200 µg/ml | $322.00 | |||
MYBPC3 Antibody (G-7): m-IgGκ BP-HRP Bundle | sc-521464 | 200 µg Ab, 40 µg BP | $361.00 | |||
MYBPC3 Antibody (G-7): m-IgG1 BP-HRP Bundle | sc-533494 | 200 µg Ab; 20 µg BP | $361.00 | |||
MYBPC3 Antibody (G-7) AC | sc-137237 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MYBPC3 Antibody (G-7) HRP | sc-137237 HRP | 200 µg/ml | $322.00 | |||
MYBPC3 Antibody (G-7) FITC | sc-137237 FITC | 200 µg/ml | $336.00 | |||
MYBPC3 Antibody (G-7) PE | sc-137237 PE | 200 µg/ml | $349.00 | |||
MYBPC3 Antibody (G-7) Alexa Fluor® 488 | sc-137237 AF488 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (G-7) Alexa Fluor® 546 | sc-137237 AF546 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (G-7) Alexa Fluor® 594 | sc-137237 AF594 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (G-7) Alexa Fluor® 647 | sc-137237 AF647 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (G-7) Alexa Fluor® 680 | sc-137237 AF680 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (G-7) Alexa Fluor® 790 | sc-137237 AF790 | 200 µg/ml | $364.00 |