MYBPC3 Inhibitors
MYBPC3 inhibitors are a class of chemical compounds that primarily target the myosin-binding protein C3 (MYBPC3) within the human body. MYBPC3 is a vital protein found in cardiac muscle tissues and plays a significant role in regulating cardiac muscle contraction and relaxation. These inhibitors are designed to modulate the function of MYBPC3, leading to alterations in the mechanical properties of cardiac muscle fibers. By doing so, they have the ability to impact the contractile properties of the heart muscle.
The mechanism of action of MYBPC3 inhibitors involves their ability to bind to the MYBPC3 protein, which is part of the sarcomere, the basic contractile unit of cardiac muscle. When MYBPC3 inhibitors interact with MYBPC3, they can influence the interactions between myosin and actin filaments, two key proteins involved in muscle contraction. This modulation of the sarcomeric proteins may result in changes in the force of contraction and the rate of relaxation of cardiac muscle fibers. While the precise details of how MYBPC3 inhibitors affect these interactions may vary depending on the specific compound, the overarching goal is to regulate cardiac muscle function by targeting MYBPC3. Research into MYBPC3 inhibitors is ongoing, with the aim of better understanding their impact on cardiac muscle physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can inhibit DNA methylation, potentially leading to the downregulation of MYBPC3 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, it may increase histone acetylation levels, influencing MYBPC3 gene expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
This DNA methyltransferase inhibitor could lead to hypomethylation of the MYBPC3 gene, altering its expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-azacytidine, decitabine can inhibit DNA methylation, potentially affecting MYBPC3 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a histone deacetylase inhibitor that may alter chromatin structure and reduce MYBPC3 expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Though primarily used for alcohol aversion therapy, disulfiram has been shown to affect gene expression, potentially including MYBPC3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
This natural compound has been studied for its ability to modulate gene expression, which could include MYBPC3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As an isoflavone, genistein can act as an epigenetic modulator, possibly influencing MYBPC3 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known for its antioxidant properties, but it also has the potential to affect gene expression, including MYBPC3. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane has been studied for its ability to modulate gene expression. | ||||||