Mx1 Antibody (E-5): sc-271024

Mx1 Antibody (E-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mx1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Mx1 antibody (E-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mx1 protein, also known as myxovirus resistance protein 1, plays a crucial role in immune response to viral infections, particularly in nuclear localization. Nuclear localization allows Mx1 to exert antiviral effects directly at viral replication sites, providing selective resistance to highly pathogenic viruses such as H5N1 influenza virus. Upon induction by interferon-alpha and interferon-beta, Mx1 accumulates in the nucleus, interfering with viral life cycles and inhibiting viral replication to enhance host defense mechanisms. Mx1′s interaction with other proteins in immune signaling pathways further underscores importance in host antiviral response.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Mx1 Antibody (E-5) References:

1. Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus.  |  Jin, HK., et al. 1999. J Virol. 73: 4925-30. PMID: 10233954
2. Functional diversity of Mx proteins: variations on a theme of host resistance to infection.  |  Lee, SH. and Vidal, SM. 2002. Genome Res. 12: 527-30. PMID: 11932237
3. Mouse Mx2 protein inhibits vesicular stomatitis virus but not influenza virus.  |  Zürcher, T., et al. 1992. Virology. 187: 796-800. PMID: 1312277
4. INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE.  |  LINDENMANN, J. 1964. Proc Soc Exp Biol Med. 116: 506-9. PMID: 14193387
5. The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses.  |  Tumpey, TM., et al. 2007. J Virol. 81: 10818-21. PMID: 17652381
6. Mx1 gene protects mice against the highly lethal human H5N1 influenza virus.  |  Salomon, R., et al. 2007. Cell Cycle. 6: 2417-21. PMID: 17700072
7. Identification of a second interferon-regulated murine Mx gene.  |  Staeheli, P. and Sutcliffe, JG. 1988. Mol Cell Biol. 8: 4524-8. PMID: 2460745
8. Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter.  |  Hug, H., et al. 1988. Mol Cell Biol. 8: 3065-79. PMID: 2974922
9. Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus.  |  Staeheli, P., et al. 1986. Cell. 44: 147-58. PMID: 3000619

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mx1 Antibody (E-5) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Mx1 Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mx1 Antibody (E-5) Specifications

Alternate Product Name: Mx1

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 171-455

Epitope Target: Mx1

Epitope Species: human

Product Reactivity/Detection: Mx1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Mx1 Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Mx1/2/3 antibody is Mx1/2/3 Antibody (C-1): sc-166412.