mtTFA Antibody (F-6): sc-166965

mtTFA Antibody (F-6) is a mouse monoclonal IgG2b kappa light chain antibody that specifically targets an epitope mapping between amino acids 198-214 within an internal region of mtTFA of mouse origin, and demonstrates reactivity with mtTFA of mouse, rat, and human origin in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). mtTFA, also known as mitochondrial transcription factor A, TFAM, or TCF6, is a nuclear-encoded protein imported into mitochondria, where mtTFA plays a crucial role in mitochondrial biogenesis by regulating the replication and transcription of mitochondrial DNA (mtDNA). mtTFA function is essential for maintaining mtDNA copy number and integrity, which is vital for proper mitochondrial function and energy production in cells. Alterations in mtTFA expression have been linked to mitochondrial disorders characterized by symptoms like ocular myopathy, exercise intolerance, and muscle wasting, underscoring mtTFA importance in human health. During spermatogenesis in mice and humans, a reduction in mtTFA protein levels leads to decreased mtDNA copy number, which may help prevent paternal mtDNA transmission. anti-mtTFA antibody (F-6) is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, making anti-mtTFA antibody (F-6) versatile for different research applications involving mitochondrial function and diseases.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mtTFA Antibody (F-6) has 85 citations in a variety of scientific publications.

Primary antibodies like Anti-mtTFA Antibody (F-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mtTFA Antibody (F-6) Specifications

Alternate Product Name: mtTFA

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 198-214

Epitope Target: mtTFA

Epitope Species: mouse

Product Reactivity/Detection: mtTFA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 85 citations in various scientific publications

Available Conjugates/Forms for mtTFA Antibody (F-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent

The preferred mtTFA antibody is mtTFA Antibody (C-9): sc-376672.