MRP1 Antibody (xQRCL-3) recommended for detection of MRP1 of human origin by IF and FCM

MRP1 Antibody (xQRCL-3): sc-18873

MRP1 Antibody (xQRCL-3) is rated 4.0 out of 5 by 4.
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Datasheets

    • MRP1 Antibody (xQRCL-3) is a mouse monoclonal IgG2a (kappa light chain) provided at 200 µg/ml
    • raised against membranes prepared from the human small cell lung cancer cell line, H69AR, which highly overexpresses MRP1
    • recommended for detection of MRP1 of human origin by IF and FCM
    • available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
    • See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
    • See MRP1 (QCRL-1): sc-18835 for MRP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
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I was wondering if the antibody MRP1 (xQRCL-3): sc-18873 recognizes an extra or intracellular epitope ? Because we want to use it for flux cytometry, but we do not want to permeabilize our cells. Thank you

Asked by: Hugosugier
Thank you for your question. This antibody was raised against membranes prepared from the human small cell lung cancer cell line, H69AR, which highly overexpresses MRP1. The exact epitope has not been mapped, so further information is not available.
Answered by: Tech Service
Date published: 2019-07-03

what is the difference between MRP1 Antibody (xQCRL3):sc-18873 and (QCRL1):sc-18835? My target is H69AR resistant to adryamycin, which one is better? I'll use FCM technique, better to buy sc-18873 FITC or buy m-IgGκ BP-FITC: sc-516140 separately? thanks

Asked by: leonardo23
Thank you for your question. These are two different monoclonal antibodies. They recognize distinct epitopes and are suitable for different applications. We do not have any recommendation for antibodies to detect H69AR resistant to adryamycin. If you would like to detect MRP1 by FCM then we do recommend using a directly conjugated primary antibody. For example, sc-18873 FITC, or sc-18835 FITC.
Answered by: Technical Support
Date published: 2019-01-26

How can MRP1 (QCRL-3): sc-18873 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: Germaine
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-18873 PE) or fluoroscein (sc-18873 FITC).
Answered by: Technical Support
Date published: 2017-02-28
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Rated 4 out of 5 by from Published IHC(P) data for use in human liver Published IHC(P) data for use in human liver. -SCBT Publication Review
Date published: 2015-03-22
Rated 4 out of 5 by from Published data for WB in human CL3 cells Published data for WB in human CL3 cells. -SCBT Publication Review
Date published: 2015-03-15
Rated 4 out of 5 by from Produced wonderful immunofluorescence membrane Produced wonderful immunofluorescence membrane staining in methanol-fixed T98G cells. -SCBT QC
Date published: 2015-02-19
Rated 4 out of 5 by from Great FCM data of human peripheral blood Great FCM data of human peripheral blood leukocytes. -SCBT QC
Date published: 2014-08-21
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