MRP1 Antibody (QCRL-3): sc-18873
- MRP1 Antibody (QCRL-3) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- raised against membranes prepared from the human small cell lung cancer cell line, H69AR, which highly overexpresses MRP1
- recommended for detection of MRP1 of human origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See MRP1 (QCRL-1): sc-18835 for MRP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MRP1 Antibody (QCRL-3). These reagents are now offered in bundles with MRP1 Antibody (QCRL-3) (see ordering information below).
MRP1 Antibody (QCRL-3) is a mouse monoclonal IgG2a antibody that detects MRP1 in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. MRP1, or multidrug-resistance protein 1, plays a crucial role in the cellular defense mechanism against toxic compounds, including chemotherapeutic agents, by actively transporting a variety of substrates out of cells. This function is particularly important in the context of cancer, where overexpression of MRP1 can lead to multidrug resistance, making MRP1 a significant target for therapeutic intervention. MRP1 is primarily localized in the plasma membrane of various cell types, including those in the lungs, testis, and peripheral blood, which underscores MRP1′s importance in protecting these tissues from harmful substances. MRP1′s structure features an Mdr-like core and a unique N-terminal membrane-bound region, which are essential for transport activity and substrate specificity. Understanding the localization and function of MRP1 is vital for developing strategies to overcome drug resistance in cancer therapy, making MRP1 monoclonal antibody (QCRL-3) an invaluable tool for researchers studying multidrug resistance mechanisms in human cells.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP1 Antibody (QCRL-3) | sc-18873 | 200 µg/ml | $322.00 | |||
MRP1 Antibody (QCRL-3): m-IgG Fc BP-HRP Bundle | sc-536604 | 200 µg Ab; 10 µg BP | $361.00 | |||
MRP1 Antibody (QCRL-3): m-IgGκ BP-HRP Bundle | sc-533759 | 200 µg Ab; 40 µg BP | $361.00 | |||
MRP1 Antibody (QCRL-3): m-IgG2a BP-HRP Bundle | sc-547842 | 200 µg Ab; 10 µg BP | $361.00 | |||
MRP1 Antibody (QCRL-3) FITC | sc-18873 FITC | 200 µg/ml | $336.00 | |||
MRP1 Antibody (QCRL-3) PE | sc-18873 PE | 200 µg/ml | $349.00 |