MRP1 Substrates

Santa Cruz Biotechnology now offers a broad range of MRP1 Substrates for use in various applications. Multidrug resistance protein 1 (MRP1) is a member of the ATP-binding cassette (ABC) transporter family, playing a critical role in the cellular efflux of a variety of substrates, including drugs, toxins, and endogenous compounds such as glutathione, glucuronides, and cyclic nucleotides. MRP1 is particularly significant in the context of multidrug resistance in cancer, where its activity can lead to decreased intracellular concentrations of chemotherapeutic agents, thereby reducing their efficacy. MRP1 Substrates are essential tools in scientific research, allowing researchers to study the transport activity of MRP1 and its impact on cellular drug resistance and detoxification processes. By utilizing these substrates, scientists can investigate how MRP1 mediates the export of various compounds from cells, contributing to a better understanding of its role in normal physiological processes as well as in pathological conditions such as cancer. These substrates are widely used in assays to measure MRP1 activity, explore the interactions between MRP1 and different substrates, and develop potential inhibitors that could help overcome drug resistance in cancer therapy. Additionally, MRP1 Substrates are valuable for studying the transport mechanisms of other related ABC transporters, providing insights into the broader implications of transporter-mediated drug disposition and resistance. The availability of these substrates has significantly advanced research in toxicology and oncology, offering critical tools for understanding the complex dynamics of drug transport and resistance at the cellular level. View detailed information on our available MRP1 Substrates by clicking on the product name.