MRP1 Antibody (E-5): sc-365635

MRP1 Antibody (E-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects MRP1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP1 (E-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MRP1, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in conferring multidrug resistance in human cancer cells, making MRP1 a significant target for cancer research. This integral membrane protein is primarily located in the plasma membrane of various cell types, including those in the brain, lungs, testis, and peripheral blood, which is vital for MRP1′s function in transporting a wide range of substrates, including drugs and endogenous compounds, across cellular membranes. Proper localization of MRP1 is essential for maintaining cellular homeostasis and protecting cells from toxic substances, as MRP1′s activity can influence the efficacy of chemotherapy treatments. MRP1 interacts with other proteins within the ABC transporter family, such as MRP2 and MRP3, which also contribute to the transport of organic anions and play roles in drug resistance mechanisms. Understanding MRP1 dynamics and interactions is critical for developing strategies to overcome drug resistance in cancer therapy.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MRP1 Antibody (E-5) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-MRP1 Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MRP1 Antibody (E-5) Specifications

Alternate Product Name: MRP1

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1497-1531

Epitope Target: MRP1

Epitope Species: human

Product Reactivity/Detection: MRP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for MRP1 Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred MRP1 antibody is MRP1 Antibody (QCRL-1): sc-18835.