MPP4 Antibody (E-6): sc-393587

MPP4 Antibody (E-6) is a mouse monoclonal IgG2a antibody that detects MPP4 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MPP4, also known as membrane protein, palmitoylated 4, MAGUK p55 subfamily member 4, ALS2CR5, discs large homolog 6 (DLG6), or amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein, is a 637 amino acid protein belonging to the MAGUK family, which is crucial for the development of retinal photoreceptors. MPP4 is predominantly expressed in the retina, with lower levels found in the testis and brain, highlighting a specialized role in visual function. MPP4 features a complex structure that includes one guanylate kinase-like domain, one SH3 domain, one PDZ (DHR) domain, and two L27 domains, which are essential for interactions and functions within cellular signaling pathways. Alternative splicing of MPP4 results in five distinct isoforms, each potentially contributing to diverse roles in cellular processes. MPP4 has been implicated in autosomal recessive retinitis pigmentosa 26 (RP26), as MPP4 co-localizes with the associated gene on human chromosome 2q33.1, underscoring significance in retinal health and disease. Anti-MPP4 antibody (E-6) is an invaluable tool for researchers investigating the molecular mechanisms underlying retinal development and associated disorders.

The preferred MPP4 antibody is MPP4 Antibody (B-2): sc-166396.