MORF4/L1/2 Antibody (D-9): sc-514659
- MORF4/L1/2 Antibody (D-9) is a mouse monoclonal IgG2a κ MORF4/L1/2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 152-178 within an internal region of MORF4L1 of human origin
- recommended for detection of MORF4L1 and MORF4L2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MORF4/L1/2 Antibody (D-9) for WB applications. These reagents are now offered in bundles with MORF4/L1/2 Antibody (D-9) (see ordering information below).
MORF4/L1/2 Antibody (D-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects MORF4/L1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MORF4/L1/2 (D-9) antibody is available as a non-conjugated format. The MORF4/L1/2 protein family includes mortality factor 4 (MORF4), mortality factor 4 like 1 (MORF4L1), also known as MORF4-related gene 15 (MRG15), and mortality factor 4 like 2 (MORF4L2), also referred to as MORF-4 related gene X (MRGX). The human MORF4 gene is located on chromosome 4q34.1, while MORF4L1 and MORF4L2 are mapped to chromosomes 15q25.1 and Xq22.2, respectively. A notable feature of these proteins is their C-terminal leucine zipper, which is crucial for protein-protein interactions and may influence their functional roles in cellular processes. Specifically, MORF4L1 has been shown to interact with retinoblastoma tumor suppressor protein (Rb) and PAM14, indicating involvement in transcriptional regulation. Additionally, MORF4L1 associates with histone acetyl transferase MOF, further linking MORF4L1 to chromatin remodeling and gene expression modulation. The interactions among MORF4, MORF4L1, and MORF4L2 with mSin3A and TLE (transducin-like enhancer of split) suggest a potential role in transcriptional repression, which is particularly important in cellular senescence and tumor suppression. In Purkinje cells, MORF4L1 is localized to both dendrites and nuclei, highlighting MORF4L1′s significance in neuronal function and signaling pathways.
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MORF4/L1/2 Antibody (D-9) References:
- MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. | Leung, JK., et al. 2001. J Biol Chem. 276: 39171-8. PMID: 11500496
- A chromodomain-containing nuclear protein, MRG15 is expressed as a novel type of dendritic mRNA in neurons. | Matsuoka, Y., et al. 2002. Neurosci Res. 42: 299-308. PMID: 11985882
- Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. | Yochum, GS. and Ayer, DE. 2002. Mol Cell Biol. 22: 7868-76. PMID: 12391155
- MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. | Pardo, PS., et al. 2002. J Biol Chem. 277: 50860-6. PMID: 12397079
- Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. | Bertram, MJ., et al. 1999. Mol Cell Biol. 19: 1479-85. PMID: 9891081
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MORF4/L1/2 Antibody (D-9) | sc-514659 | 200 µg/ml | $322.00 | |||
MORF4/L1/2 Antibody (D-9): m-IgGκ BP-HRP Bundle | sc-536339 | 200 µg Ab; 40 µg BP | $361.00 | |||
MORF4/L1/2 Antibody (D-9): m-IgG2a BP-HRP Bundle | sc-546230 | 200 µg Ab; 10 µg BP | $361.00 | |||
MORF4/L1/2 (D-9) Neutralizing Peptide | sc-514659 P | 100 µg/0.5 ml | $69.00 |