MORF4L1/2 Antibody (E-2): sc-393208

MORF4L1/2 Antibody (E-2) is a mouse monoclonal IgM antibody that detects MORF4L1 and MORF4L2 proteins from mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MORF4L1/2 (E-2) antibody is available in a non-conjugated form, providing researchers with a versatile tool for studying these important proteins. The mortality factor 4 family, which includes MORF4, MORF4L1, and MORF4L2, plays a crucial role in cellular processes, particularly in transcription regulation and cellular senescence. MORF4L1, also known as mortality factor 4-like 1, is located in the nucleus and dendrites of Purkinje cells, highlighting MORF4L1′s significance in neuronal function. MORF4L1 contains a C-terminal leucine zipper, which is essential for protein-protein interactions, and MORF4L1 has been shown to associate with key regulatory proteins such as the retinoblastoma tumor suppressor (Rb) and the histone acetyl transferase MOF. These interactions suggest MORF4L1′s involvement in the modulation of gene expression, particularly in the context of cellular aging and differentiation. MORF4L1 and MORF4L2 genes are located on chromosomes 15q25.1 and Xq22.2, respectively, and MORF4L1/2 expression is tightly regulated, making these proteins important targets for research in cancer and developmental biology.

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MORF4L1/2 Antibody (E-2) References:

1. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14.  |  Leung, JK., et al. 2001. J Biol Chem. 276: 39171-8. PMID: 11500496
2. A chromodomain-containing nuclear protein, MRG15 is expressed as a novel type of dendritic mRNA in neurons.  |  Matsuoka, Y., et al. 2002. Neurosci Res. 42: 299-308. PMID: 11985882
3. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split.  |  Yochum, GS. and Ayer, DE. 2002. Mol Cell Biol. 22: 7868-76. PMID: 12391155
4. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation.  |  Pardo, PS., et al. 2002. J Biol Chem. 277: 50860-6. PMID: 12397079
5. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.  |  Bertram, MJ., et al. 1999. Mol Cell Biol. 19: 1479-85. PMID: 9891081

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MORF4L1/2 Antibody (E-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MORF4L1/2 Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MORF4L1/2 Antibody (E-2) Specifications

Alternate Product Name: MORF4L1/2

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 250-297

Epitope Target: MORF4L1

Epitope Species: human

Product Reactivity/Detection: MORF4L1 and MORF4L2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MORF4L1/2 Antibody (E-2): P: Blocking Peptide