MMP-12 Antibody (H-9): sc-390284

MMP-12 Antibody (H-9) is a mouse monoclonal IgG2a light chain antibody that detects MMP-12 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MMP-12, also known as macrophage metalloelastase, plays a crucial role in the degradation of elastin, a key component of the extracellular matrix that provides structural support to tissues. MMP-12 is primarily produced in alveolar macrophages, where MMP-12 is involved in the remodeling of lung tissue and the inflammatory response. The ability of MMP-12 to degrade elastin is particularly important in the context of granulomatous skin diseases, as excessive elastin degradation can lead to tissue damage and impaired healing. Furthermore, MMP-12 is implicated in macrophage migration through the epidermal and vascular basement membranes, which is essential for the immune response during inflammatory disorders. Anti-MMP-12 antibody (H-9) enables researchers to gain valuable insights into the role of this enzyme in various pathological conditions, enhancing our understanding of its function in health and disease.

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MMP-12 Antibody (H-9) References:

1. Retinal MMP-12, MMP-13, TIMP-1, and TIMP-2 expression in murine experimental retinal detachment.  |  Kim, B., et al. 2014. Invest Ophthalmol Vis Sci. 55: 2031-40. PMID: 24526442
2. Optical imaging of MMP-12 active form in inflammation and aneurysm.  |  Razavian, M., et al. 2016. Sci Rep. 6: 38345. PMID: 27917892
3. MMP Gene Polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and Ischemic Stroke: A Meta-Analysis.  |  Zhang, G., et al. 2018. J Stroke Cerebrovasc Dis. 27: 140-152. PMID: 28958661
4. MMP-12 and S100s in saliva reflect different aspects of periodontal inflammation.  |  Holmström, SB., et al. 2019. Cytokine. 113: 155-161. PMID: 29983358
5. MMP-12-Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells.  |  Deng, XS., et al. 2019. J Surg Res. 235: 44-51. PMID: 30691826
6. MMP-12 regulates proliferation of mouse macrophages via the ERK/P38 MAPK pathways during inflammation.  |  Guan, C., et al. 2019. Exp Cell Res. 378: 182-190. PMID: 30880028
7. MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients.  |  Wang, CY., et al. 2020. Med Hypotheses. 136: 109524. PMID: 31862687
8. Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud's arthropathy and a distinctive MRI pattern.  |  Piga, M., et al. 2021. Rheumatology (Oxford). 60: 4218-4228. PMID: 33404658
9. Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.  |  Cárcel-Márquez, J., et al. 2021. Stroke. 52: e316-e320. PMID: 33902302
10. Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis.  |  Zhao, H., et al. 2024. Arch Med Sci. 20: 196-206. PMID: 38414455

The preferred MMP-12 antibody is MMP-12 Antibody (G-2): sc-390863.